No major host genetic risk factor contributed to A(H1N1)2009 influenza severity
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- dc.contributor.author Garcia Etxebarria, Koldoca
- dc.contributor.author Bracho, María Almaca
- dc.contributor.author Galán, Juan Carlosca
- dc.contributor.author Pumarola, Tomásca
- dc.contributor.author Castilla, Jesúsca
- dc.contributor.author Ortiz de Lejarazu, Raúlca
- dc.contributor.author Rodríguez Domínguez, Marioca
- dc.contributor.author Quintela Garcia, Inesca
- dc.contributor.author Bonet, Núriaca
- dc.contributor.author García Garcerà, Marcca
- dc.contributor.author Domínguez García, Àngelaca
- dc.contributor.author González Candela, Fernandoca
- dc.contributor.author Calafell i Majó, Francescca
- dc.date.accessioned 2016-01-28T15:09:01Z
- dc.date.available 2016-01-28T15:09:01Z
- dc.date.issued 2015
- dc.description.abstract While most patients affected by the influenza A(H1N1) pandemic experienced mild symptoms, a small fraction required hospitalization, often without concomitant factors that could explain such a severe course. We hypothesize that host genetic factors could contribute to aggravate the disease. To test this hypothesis, we compared the allele frequencies of 547,296 genome-wide single nucleotide polymorphisms (SNPs) between 49 severe and 107 mild confirmed influenza A cases, as well as against a general population sample of 549 individuals. When comparing severe vs. mild influenza A cases, only one SNP was close to the conventional p = 5×10-8. This SNP, rs28454025, sits in an intron of the GSK233 gene, which is involved in a neural development, but seems not to have any connections with immunological or inflammatory functions. Indirectly, a previous association reported with CD55 was replicated. Although sample sizes are low, we show that the statistical power in our design was sufficient to detect highly-penetrant, quasi-Mendelian genetic factors. Hence, and assuming that rs28454025 is likely to be a false positive, no major genetic factor was detected that could explain poor influenza A course.ca
- dc.description.sponsorship Funding for this work came from Instituto de Salud Carlos III (Madrid, Spain; www.isciii.es) grant GR09/0032.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Garcia-Etxebarria K, Bracho MA, Galán JC, Pumarola T, Castilla J, Ortiz de Lejarazu R et al. No major host genetic risk factor contributed to A(H1N1)2009 influenza severity. PLoS One. 2015;10(9):e135983. DOI: 10.1371/journal.pone.0135983ca
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0135983
- dc.identifier.issn 1553-7390
- dc.identifier.uri http://hdl.handle.net/10230/25689
- dc.language.iso engca
- dc.publisher Public Library of Science (PLoS)ca
- dc.relation.ispartof PLoS One. 2015;10(9):e135983
- dc.rights © 2015 Garcia-Etxebarria et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
- dc.subject.other Gripca
- dc.subject.other RNAca
- dc.title No major host genetic risk factor contributed to A(H1N1)2009 influenza severityca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca