Soluble transferrin receptor as iron deficiency biomarker: Impact on exercise capacity in heart failure patients

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• dc.contributor.author Ras Jiménez, Maria del Mar
• dc.contributor.author Ramos Polo, Raúl
• dc.contributor.author Francesch Manzano, Josep
• dc.contributor.author Corbella Santano, Miriam
• dc.contributor.author Morillas Climent, Herminio
• dc.contributor.author José Bazán, Núria
• dc.contributor.author Jiménez Marrero, Santiago
• dc.contributor.author Garcimartín Cerezo, Paloma
• dc.contributor.author Yun, Sergi
• dc.contributor.author Moliner Borja, Pedro
• dc.contributor.author Torres Cardús, Blanca
• dc.contributor.author Verdú-Rotellar, José María
• dc.contributor.author Díez López, Carles
• dc.contributor.author González Costello, José
• dc.contributor.author García-Romero, Elena
• dc.contributor.author Frutos Seminario, Fernando de
• dc.contributor.author Triguero Llonch, Laura
• dc.contributor.author Enjuanes Grau, Cristina
• dc.contributor.author Tajes Orduña, Marta
• dc.contributor.author Comín Colet, Josep
• dc.date.accessioned 2024-05-22T07:24:19Z
• dc.date.available 2024-05-22T07:24:19Z
• dc.date.issued 2023
• dc.description.abstract The soluble transferrin receptor (sTfR) is a marker of tissue iron status, which could indicate an increased iron demand at the tissue level. The impact of sTfR levels on functional capacity and quality of life (QoL) in non-anemic heart failure (HF) patients with otherwise normal systemic iron status has not been evaluated. We conducted an observational, prospective, cohort study of 1236 patients with chronic HF. We selected patients with normal hemoglobin levels and normal systemic iron status. Tissue iron deficiency (ID) was defined as levels of sTfR > 75th percentile (1.63 mg per L). The primary endpoints were the distance walked in the 6 min walking test (6MWT) and the overall summary score (OSS) of the Minnesota Living with Heart Failure Questionnaire (MLHFQ). The final study cohort consisted of 215 patients. Overall QoL was significantly worse (51 ± 27 vs. 39 ± 20, p-value = 0.006, respectively), and the 6 MWT distance was significantly worse in patients with tissue ID when compared to patients without tissue ID (206 ± 179 m vs. 314 ± 155, p-value < 0.0001, respectively). Higher sTfR levels, indicating increased iron demand, were associated with a shorter distance in the 6 MWT (standardized β = -0.249, p < 0.001) and a higher MLHFQ OSS (standardized β = 0.183, p-value = 0.008). In this study, we show that in patients with normal systemic iron parameters, higher levels of sTfR are strongly associated with an impaired submaximal exercise capacity and with worse QoL.
• dc.format.mimetype application/pdf
• dc.identifier.citation Ras-Jiménez MDM, Ramos-Polo R, Francesch Manzano J, Corbella Santano M, Morillas Climent H, Jose-Bazán N, et al. Soluble transferrin receptor as iron deficiency biomarker: Impact on exercise capacity in heart failure patients. J Pers Med. 2023 Aug 21;13(8):1282. DOI: 10.3390/jpm13081282
• dc.identifier.doi http://dx.doi.org/10.3390/jpm13081282
• dc.identifier.issn 2075-4426
• dc.identifier.uri http://hdl.handle.net/10230/60216
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof J Pers Med. 2023 Aug 21;13(8):1282
• dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword 6 min walking test (6MWT)
• dc.subject.keyword Minnesota Living with Heart Failure Questionnaire (MLHFQ)
• dc.subject.keyword Heart failure
• dc.subject.keyword Iron deficiency
• dc.subject.keyword Quality of life
• dc.subject.keyword Soluble transferrin receptor
• dc.subject.keyword Submaximal functional capacity
• dc.title Soluble transferrin receptor as iron deficiency biomarker: Impact on exercise capacity in heart failure patients
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion