Association between the use of folic acid supplements during pregnancy and children's cognitive function at 7-9 years of age in the INMA cohort study

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  • dc.contributor.author Compañ Gabucio, Laura María
  • dc.contributor.author Torres-Collado, Laura
  • dc.contributor.author García-de-la-Hera, Manoli
  • dc.contributor.author Fernández-Somoano, Ana
  • dc.contributor.author Tardón, Adonina
  • dc.contributor.author Júlvez Calvo, Jordi
  • dc.contributor.author Sunyer Deu, Jordi
  • dc.contributor.author Rebagliato, Marisa
  • dc.contributor.author Murcia, Mario
  • dc.contributor.author Ibarluzea, Jesús
  • dc.contributor.author Santa Marina, Loreto
  • dc.contributor.author Vioque, Jesus
  • dc.date.accessioned 2022-12-13T09:21:47Z
  • dc.date.available 2022-12-13T09:21:47Z
  • dc.date.issued 2022
  • dc.description.abstract This study investigated the association between maternal low (<400 μg/day) or high (≥1000 μg/day) folic acid supplements (FAs) use during pregnancy and the attentional function and working memory in boys and girls at age 7-9. A longitudinal analysis based on 1609 mother-child pairs from the Spanish Infancia y Medio Ambiente Project was carried out. Multivariable regression analyses revealed that, compared to the recommended FAs use, a low FAs use during the second period of pregnancy was associated with a lower alertness in all children (β = 18.70 ms; 95% CI: 7.51; 29.89) and in girls (β = 30.01 ms; 95% CI: 12.96; 47.01), and with a lower N-back Task performance in boys (d' number 2-back (β = -0.25; 95% CI: -0.49; 0.01)). A high FAs use throughout the two periods of pregnancy was associated with a better N-back Task performance only in girls (d' number 2-back (β = 0.28; 95% CI: 0.01; 0.56) and d' number 3-back (β = 0.32; 95% CI: 0.08; 0.56)). The maternal use of FAs beyond the periconceptional period may affect children's attentional function and working memory at age 7-9 differently for boys and girls.
  • dc.description.sponsorship This research was funded by Grants from the UE (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1); Spanish Institute of Health Carlos III-Ministry of Economy and Competitiveness (Red INMA G03/176, CB06/02/0041; FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI04/2018, PI05/1079,PI05/1052, PI06/1213, PI06/0867, PI07/0314, PI09/02311, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI12/00610, PI13/02429, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, PI17/00663, PI04/1436, PI08/1151, PI04/2018, PI09/02311, PI13/02429, FISS-19-PI18-00909, PI18/01142, and PI09/00090, incl. FEDER funds; Miguel Servet-FEDER CP11/00178, CP15/00025, and CPII16/00051); Generalitat Valenciana (FISABIO UGP 15-230, UGP-15-244, and UGP-15-249, Grupos de Investigación Consolidados AICO/2021/347); Generalitat de Catalunya-CIRIT (1999SGR 00241); ISGlobal is a member of the CERCA Programme; Fundació La marató de TV3 (090430); CIBERESP; Obra Social Cajastur/Fundación Liberbank; Universidad de Oviedo; Alicia Koplowitz Foundation 2017; Department of Health of the Basque Government (2005111093); Department of Health of the Basque Government (2013111089); Provincial Government of Gipuzkoa (DFG06/002); and annual agreements with the municipalities of the study area (Zumárraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain). This study has been funded by Instituto de Salud Carlos III through the projects “PI16/00261 and PI21/00266” (co-funded by European Regional Development Fund “A way to make Europe”) and PI18/00909 (co-funded by FEDER, “A way to make Europe”/“Investing in your future”). Jordi Julvez holds the Miguel Servet-II contract (CPII19/00015) awarded by the Instituto de Salud Carlos III (co-funded by the European Social Fund “Investing in your future”). This study was funded by Universidad Miguel Hernández through “AYUDAS A LA INVESTIGACIÓN VICERRECTORADO DE INVESTIGACIÓN 2022”.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Compañ-Gabucio LM, Torres-Collado L, Garcia-de la Hera M, Fernández-Somoano A, Tardón A, Julvez J, Sunyer J, Rebagliato M, Murcia M, Ibarluzea J, Santa-Marina L, Vioque J. Association between the use of folic acid supplements during pregnancy and children's cognitive function at 7-9 years of age in the INMA cohort study. Int J Environ Res Public Health. 2022 Sep 25;19(19):12123. DOI: 10.3390/ijerph191912123
  • dc.identifier.doi http://dx.doi.org/10.3390/ijerph191912123
  • dc.identifier.issn 1661-7827
  • dc.identifier.uri http://hdl.handle.net/10230/55123
  • dc.language.iso eng
  • dc.publisher MDPI
  • dc.relation.ispartof Int J Environ Res Public Health. 2022 Sep 25;19(19):12123
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
  • dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri https://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Attentional function
  • dc.subject.keyword Birth cohort study
  • dc.subject.keyword Deficiency
  • dc.subject.keyword Folic acid
  • dc.subject.keyword Folic acid
  • dc.subject.keyword High
  • dc.subject.keyword Sex specific
  • dc.subject.keyword Working memory
  • dc.title Association between the use of folic acid supplements during pregnancy and children's cognitive function at 7-9 years of age in the INMA cohort study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Articles (Departament de Medicina i Ciències de la Vida)
Articles (Hospital del Mar Research Institute)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)