Modeling tumors as complex ecosystems
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- dc.contributor.author Aguadé Gorgorió, Guim, 1991-
- dc.contributor.author Anderson, Alexander R. A.
- dc.contributor.author Solé Vicente, Ricard, 1962-
- dc.date.accessioned 2025-04-03T06:09:07Z
- dc.date.available 2025-04-03T06:09:07Z
- dc.date.issued 2024
- dc.description.abstract Many cancers resist therapeutic intervention. This is fundamentally related to intratumor heterogeneity: multiple cell populations, each with different phenotypic signatures, coexist within a tumor and its metastases. Like species in an ecosystem, cancer populations are intertwined in a complex network of ecological interactions. Most mathematical models of tumor ecology, however, cannot account for such phenotypic diversity or predict its consequences. Here, we propose that the generalized Lotka-Volterra model (GLV), a standard tool to describe species-rich ecological communities, provides a suitable framework to model the ecology of heterogeneous tumors. We develop a GLV model of tumor growth and discuss how its emerging properties provide a new understanding of the disease. We discuss potential extensions of the model and their application to phenotypic plasticity, cancer-immune interactions, and metastatic growth. Our work outlines a set of questions and a road map for further research in cancer ecology.
- dc.format.mimetype application/pdf
- dc.identifier.citation Aguadé-Gorgorió G, Anderson ARA, Solé R. Modeling tumors as complex ecosystems. iScience. 2024 Aug 10;27(9):110699. DOI: 10.1016/j.isci.2024.110699
- dc.identifier.doi http://dx.doi.org/10.1016/j.isci.2024.110699
- dc.identifier.issn 2589-0042
- dc.identifier.uri http://hdl.handle.net/10230/70082
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof iScience. 2024 Aug 10;27(9):110699
- dc.rights © 2024 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Cancer
- dc.subject.keyword Cancer systems biology
- dc.subject.keyword Ecology
- dc.subject.keyword Mathematical biosciences
- dc.title Modeling tumors as complex ecosystems
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion