Breast density, benign breast disease, and risk of breast cancer over time

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• dc.contributor.author Román, Marta
• dc.contributor.author Louro, Javier
• dc.contributor.author Posso, Margarita
• dc.contributor.author Alcántara da Silva, Rodrigo
• dc.contributor.author Peñalva, Lupe
• dc.contributor.author Sala, Maria
• dc.contributor.author Del Riego, Javier
• dc.contributor.author Prieto, Miguel
• dc.contributor.author Vidal, Carmen
• dc.contributor.author Sánchez, Mar
• dc.contributor.author Bargalló Castelló, Xavier
• dc.contributor.author Tusquets, Ignasi
• dc.contributor.author Castells, Xavier
• dc.date.accessioned 2025-01-24T13:51:53Z
• dc.date.available 2025-01-24T13:51:53Z
• dc.date.issued 2021
• dc.description.abstract Objectives: Assessing the combined effect of mammographic density and benign breast disease is of utmost importance to design personalized screening strategies. Methods: We analyzed individual-level data from 294,943 women aged 50-69 years with at least one mammographic screening participation in any of four areas of the Spanish Breast Cancer Screening Program from 1995 to 2015, and followed up until 2017. We used partly conditional Cox models to assess the association between benign breast disease, breast density, and the risk of breast cancer. Results: During a median follow-up of 8.0 years, 3697 (1.25%) women had a breast cancer diagnosis and 5941 (2.01%) had a benign breast disease. More than half of screened women had scattered fibroglandular density (55.0%). The risk of breast cancer independently increased with the presence of benign breast disease and with the increase in breast density (p for interaction = 0.84). Women with benign breast disease and extremely dense breasts had a threefold elevated risk of breast cancer compared with those with scattered fibroglandular density and without benign breast disease (hazard ratio [HR] = 3.07; 95%CI = 2.01-4.68). Heterogeneous density and benign breast disease was associated with nearly a 2.5 elevated risk (HR = 2.48; 95%CI = 1.66-3.70). Those with extremely dense breast without a benign breast disease had a 2.27 increased risk (95%CI = 2.07-2.49). Conclusions: Women with benign breast disease had an elevated risk for over 15 years independently of their breast density category. Women with benign breast disease and dense breasts are at high risk for future breast cancer. Key points: • Benign breast disease and breast density were independently associated with breast cancer. • Women with benign breast disease had an elevated risk for up to 15 years independently of their mammographic density category.
• dc.format.mimetype application/pdf
• dc.identifier.citation Román M, Louro J, Posso M, Alcántara R, Peñalva L, Sala M, et al. Breast density, benign breast disease, and risk of breast cancer over time. Eur Radiol. 2021 Jul;31(7):4839-47. DOI: 10.1007/s00330-020-07490-5
• dc.identifier.doi http://dx.doi.org/10.1007/s00330-020-07490-5
• dc.identifier.issn 0938-7994
• dc.identifier.uri http://hdl.handle.net/10230/69269
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Eur Radiol. 2021 Jul;31(7):4839-47
• dc.rights This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00330-020-07490-5
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Benign breast disease
• dc.subject.keyword Breast neoplasms
• dc.subject.keyword Longitudinal studies
• dc.subject.keyword Mammographic density
• dc.subject.keyword Mass screening
• dc.title Breast density, benign breast disease, and risk of breast cancer over time
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion