Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations

Tamborero Noguera, David; Rubio Pérez, Carlota, 1990-; Déu Pons, Jordi; Schroeder, Michael Philipp, 1986-; Vivancos Prellezo, Ana; Rovira Guerín, Ana; Tusquets Trias de Bes, Ignacio; Albanell Mestres, Joan; Rodon, Jordi; Tabernero Cartula, Josep; Torres, Carmen de; Dienstmann, Rodrigo; González-Pérez, Abel; López Bigas, Núria

Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations

Mostra el registre complet Registre parcial de l'ítem

dc.contributor.author Tamborero Noguera, Davidca
dc.contributor.author Rubio Pérez, Carlota, 1990-ca
dc.contributor.author Déu Pons, Jordica
dc.contributor.author Schroeder, Michael Philipp, 1986-ca
dc.contributor.author Vivancos Prellezo, Anaca
dc.contributor.author Rovira Guerín, Anaca
dc.contributor.author Tusquets Trias de Bes, Ignacioca
dc.contributor.author Albanell Mestres, Joanca
dc.contributor.author Rodon, Jordica
dc.contributor.author Tabernero Cartula, Josepca
dc.contributor.author Torres, Carmen deca
dc.contributor.author Dienstmann, Rodrigoca
dc.contributor.author González-Pérez, Abelca
dc.contributor.author López Bigas, Núriaca
dc.date.accessioned 2018-05-09T09:39:33Z
dc.date.available 2018-05-09T09:39:33Z
dc.date.issued 2018
dc.description.abstract While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck. Here we present the Cancer Genome Interpreter, a versatile platform that automates the interpretation of newly sequenced cancer genomes, annotating the potential of alterations detected in tumors to act as drivers and their possible effect on treatment response. The results are organized in different levels of evidence according to current knowledge, which we envision can support a broad range of oncology use cases. The resource is publicly available at http://www.cancergenomeinterpreter.org.
dc.description.sponsorship This project has received funding from Fundació La Marató de TV3, the European Union's Horizon 2020 research and innovation programme 2014-2020 under grant agreement number 634143, and by the European Research Council (Consolidator Grant 682398). IRB Barcelona is a recipient of a Severo Ochoa Centre of Excellence Award from the Spanish Ministry of Economy and Competitiveness (MINECO; Government of Spain) and is supported by CERCA (Generalitat de Catalunya). DT is supported by project SAF2015-74072-JIN funded by the Agencia Estatal de Investigacion (AEI) and Fondo Europeo de Desarrollo Regional (FEDER). CR-P is funded by a FPI MINECO grant (BES-2013-063354). AG-P is supported by a Ramon y Cajal fellowship (RYC-2013-14554).
dc.format.mimetype application/pdf
dc.identifier.citation Tamborero D, Rubio-Perez C, Deu-Pons J, Schroeder MP, Vivancos A, Rovira A et al. Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations. Genome Med. 2018 Dec;10(1):25. DOI: 10.1186/s13073-018-0531-8
dc.identifier.doi http://dx.doi.org/10.1186/s13073-018-0531-8
dc.identifier.issn 1756-994X
dc.identifier.uri http://hdl.handle.net/10230/34593
dc.language.iso eng
dc.publisher BioMed Centralca
dc.relation.ispartof Genome Med. 2018 Dec;10(1):25
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634143
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/682398
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2015-74072-JIN
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BES-2013-063354
dc.rights © The Author(s). 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Neoplasms
dc.subject.keyword Cancer genome interpreter
dc.title Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterationsca
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)
Articles (Hospital del Mar Research Institute)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)