Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations

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  • dc.contributor.author Tamborero Noguera, Davidca
  • dc.contributor.author Rubio Pérez, Carlota, 1990-ca
  • dc.contributor.author Déu Pons, Jordica
  • dc.contributor.author Schroeder, Michael Philipp, 1986-ca
  • dc.contributor.author Vivancos Prellezo, Anaca
  • dc.contributor.author Rovira Guerín, Anaca
  • dc.contributor.author Tusquets Trias de Bes, Ignacioca
  • dc.contributor.author Albanell Mestres, Joanca
  • dc.contributor.author Rodon, Jordica
  • dc.contributor.author Tabernero Cartula, Josepca
  • dc.contributor.author Torres, Carmen deca
  • dc.contributor.author Dienstmann, Rodrigoca
  • dc.contributor.author González-Pérez, Abelca
  • dc.contributor.author López Bigas, Núriaca
  • dc.date.accessioned 2018-05-09T09:39:33Z
  • dc.date.available 2018-05-09T09:39:33Z
  • dc.date.issued 2018
  • dc.description.abstract While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck. Here we present the Cancer Genome Interpreter, a versatile platform that automates the interpretation of newly sequenced cancer genomes, annotating the potential of alterations detected in tumors to act as drivers and their possible effect on treatment response. The results are organized in different levels of evidence according to current knowledge, which we envision can support a broad range of oncology use cases. The resource is publicly available at http://www.cancergenomeinterpreter.org.
  • dc.description.sponsorship This project has received funding from Fundació La Marató de TV3, the European Union's Horizon 2020 research and innovation programme 2014-2020 under grant agreement number 634143, and by the European Research Council (Consolidator Grant 682398). IRB Barcelona is a recipient of a Severo Ochoa Centre of Excellence Award from the Spanish Ministry of Economy and Competitiveness (MINECO; Government of Spain) and is supported by CERCA (Generalitat de Catalunya). DT is supported by project SAF2015-74072-JIN funded by the Agencia Estatal de Investigacion (AEI) and Fondo Europeo de Desarrollo Regional (FEDER). CR-P is funded by a FPI MINECO grant (BES-2013-063354). AG-P is supported by a Ramon y Cajal fellowship (RYC-2013-14554).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Tamborero D, Rubio-Perez C, Deu-Pons J, Schroeder MP, Vivancos A, Rovira A et al. Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations. Genome Med. 2018 Dec;10(1):25. DOI: 10.1186/s13073-018-0531-8
  • dc.identifier.doi http://dx.doi.org/10.1186/s13073-018-0531-8
  • dc.identifier.issn 1756-994X
  • dc.identifier.uri http://hdl.handle.net/10230/34593
  • dc.language.iso eng
  • dc.publisher BioMed Centralca
  • dc.relation.ispartof Genome Med. 2018 Dec;10(1):25
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634143
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/682398
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2015-74072-JIN
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BES-2013-063354
  • dc.rights © The Author(s). 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Neoplasms
  • dc.subject.keyword Cancer genome interpreter
  • dc.title Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterationsca
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion