Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations

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dc.contributor.authorTamborero Noguera, Davidca
dc.contributor.authorRubio Pérez, Carlota, 1990-ca
dc.contributor.authorDéu Pons, Jordica
dc.contributor.authorSchroeder, Michael Philipp, 1986-ca
dc.contributor.authorVivancos Prellezo, Anaca
dc.contributor.authorRovira Guerín, Anaca
dc.contributor.authorTusquets Trias de Bes, Ignacioca
dc.contributor.authorAlbanell Mestres, Joanca
dc.contributor.authorRodon, Jordica
dc.contributor.authorTabernero Cartula, Josepca
dc.contributor.authorTorres, Carmen deca
dc.contributor.authorDienstmann, Rodrigoca
dc.contributor.authorGonzález-Pérez, Abelca
dc.contributor.authorLópez Bigas, Núriaca
dc.date.accessioned2018-05-09T09:39:33Z
dc.date.available2018-05-09T09:39:33Z
dc.date.issued2018
dc.description.abstractWhile tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck. Here we present the Cancer Genome Interpreter, a versatile platform that automates the interpretation of newly sequenced cancer genomes, annotating the potential of alterations detected in tumors to act as drivers and their possible effect on treatment response. The results are organized in different levels of evidence according to current knowledge, which we envision can support a broad range of oncology use cases. The resource is publicly available at http://www.cancergenomeinterpreter.org.
dc.description.sponsorshipThis project has received funding from Fundació La Marató de TV3, the European Union's Horizon 2020 research and innovation programme 2014-2020 under grant agreement number 634143, and by the European Research Council (Consolidator Grant 682398). IRB Barcelona is a recipient of a Severo Ochoa Centre of Excellence Award from the Spanish Ministry of Economy and Competitiveness (MINECO; Government of Spain) and is supported by CERCA (Generalitat de Catalunya). DT is supported by project SAF2015-74072-JIN funded by the Agencia Estatal de Investigacion (AEI) and Fondo Europeo de Desarrollo Regional (FEDER). CR-P is funded by a FPI MINECO grant (BES-2013-063354). AG-P is supported by a Ramon y Cajal fellowship (RYC-2013-14554).
dc.format.mimetypeapplication/pdf
dc.identifier.citationTamborero D, Rubio-Perez C, Deu-Pons J, Schroeder MP, Vivancos A, Rovira A et al. Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations. Genome Med. 2018 Dec;10(1):25. DOI: 10.1186/s13073-018-0531-8
dc.identifier.doihttp://dx.doi.org/10.1186/s13073-018-0531-8
dc.identifier.issn1756-994X
dc.identifier.urihttp://hdl.handle.net/10230/34593
dc.language.isoeng
dc.publisherBioMed Centralca
dc.relation.ispartofGenome Med. 2018 Dec;10(1):25
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/634143
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/682398
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/SAF2015-74072-JIN
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/BES-2013-063354
dc.rights© The Author(s). 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.keywordNeoplasms
dc.subject.keywordCancer genome interpreter
dc.titleCancer Genome Interpreter annotates the biological and clinical relevance of tumor alterationsca
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion

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