Effects of wine and tyrosol on the lipid metabolic profile of subjects at risk of cardiovascular disease: potential cardioprotective role of ceramides
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- dc.contributor.author Rodríguez-Morató, Jose, 1987-
- dc.contributor.author Boronat Rigol, Anna, 1990-
- dc.contributor.author Serreli, Gabriele
- dc.contributor.author Enríquez, Laura
- dc.contributor.author Gómez-Gómez, Àlex
- dc.contributor.author Pozo Mendoza, Óscar J., 1975-
- dc.contributor.author Fitó Colomer, Montserrat
- dc.contributor.author Torre Fornell, Rafael de la
- dc.date.accessioned 2021-11-10T07:48:42Z
- dc.date.available 2021-11-10T07:48:42Z
- dc.date.issued 2021
- dc.description.abstract Ceramides are a class of sphingolipids which have recently been shown to be better cardiovascular disease (CVD) risk predictors than traditional CVD risk biomarkers. Tyrosol (TYR) is a dietary phenolic compound known to possess cardioprotective effects per se or through its in vivo active metabolite hydroxytyrosol. The purpose of this study was to evaluate the effects of the co-administration of white wine (WW) and TYR on circulating levels of ceramides and other lipids in humans at high CVD risk. Volunteers underwent a randomized controlled crossover clinical trial (4-week duration per intervention) with three different interventions: control, WW, and WW enriched with a capsule of TYR (WW + TYR). Endothelial function cardiovascular biomarkers and plasma lipidomic profile were assessed before and after each intervention. It was found that the WW + TYR intervention resulted in lower levels of three ceramide ratios, associated with an improvement of endothelial function (Cer C16:0/Cer C24:0, Cer C18:0/Cer C24:0, and Cer C24:1/Cer C24:0), when compared to the control intervention. Moreover, WW + TYR was able to minimize the alterations in plasma diacylglycerols concentrations observed following WW. Overall, the results obtained show that the antioxidant TYR administered with WW exerts beneficial effects at the cardiovascular level, in part by modulating blood lipid profile.
- dc.format.mimetype application/pdf
- dc.identifier.citation Rodríguez-Morató J, Boronat A, Serrelli G, Enríquez L, Gomez-Gomez A, Pozo OJ, Fitó M, de la Torre R. Effects of wine and tyrosol on the lipid metabolic profile of subjects at risk of cardiovascular disease: potential cardioprotective role of ceramides. Antioxidants. 2021;10(11):1679. DOI: 10.3390/antiox10111679
- dc.identifier.doi http://dx.doi.org/10.3390/antiox10111679
- dc.identifier.issn 2076-3921
- dc.identifier.uri http://hdl.handle.net/10230/48937
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Antioxidants. 2021;10(11):1679
- dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Cardiovascular disease
- dc.subject.keyword Ceramides
- dc.subject.keyword Ethanol
- dc.subject.keyword Randomized clinical trial
- dc.subject.keyword Tyrosol
- dc.subject.keyword White wine
- dc.title Effects of wine and tyrosol on the lipid metabolic profile of subjects at risk of cardiovascular disease: potential cardioprotective role of ceramides
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion