Plasma omega-3 fatty acids and risk for incident dementia in the UK biobank study: A closer look
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- dc.contributor.author Sala Vila, Aleix
- dc.contributor.author Tintle, Nathan
- dc.contributor.author Westra, Jason
- dc.contributor.author Harris, William S.
- dc.date.accessioned 2024-11-04T06:49:18Z
- dc.date.available 2024-11-04T06:49:18Z
- dc.date.issued 2023
- dc.description.abstract Dietary omega-3 fatty acids are promising nutrients in dementia. Several prospective cohort studies have examined the relationships between circulating omega-3 (an objective biomarker of dietary intake) and incident dementia, the largest to date being a report from the UK Biobank (n = 102,722). Given the recent release of new metabolomics data from baseline samples from the UK Biobank, we re-examined the association in a much larger sample (n = 267,312) and also focused on associations with total omega-3, docosahexaenoic acid (DHA), and non-DHA omega-3. Using Cox regression models, we observed that the total omega-3 status was inversely related to the risk of Alzheimer's (Q5 vs. Q1, hazard ratio [95% confidence interval] = 0.87 [0.76; 1.00]) and all-cause dementia (Q5 vs. Q1, 0.79 [0.72; 0.87]). The strongest associations were observed for total omega-3 (and non-DHA omega-3) and all-cause dementia. In prespecified strata, we found stronger associations in men, and in those aged ≥60 years at baseline (vs. those aged 50-59). Thus, in the largest study to date on this topic, we confirmed the favorable relationships between DHA and risk for dementia, and we also found evidence that non-DHA omega-3 may be beneficial. Finally, we have better defined the populations most likely to benefit from omega-3-based interventions.
- dc.format.mimetype application/pdf
- dc.identifier.citation Sala-Vila A, Tintle N, Westra J, Harris WS. Plasma omega-3 fatty acids and risk for incident dementia in the UK biobank study: A closer look. Nutrients. 2023 Nov 23;15(23):4896. DOI: 10.3390/nu15234896
- dc.identifier.doi http://dx.doi.org/10.3390/nu15234896
- dc.identifier.issn 2072-6643
- dc.identifier.uri http://hdl.handle.net/10230/68403
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Nutrients. 2023 Nov 23;15(23):4896
- dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Alzheimer’s disease
- dc.subject.keyword DHA
- dc.subject.keyword Biomarkers
- dc.subject.keyword Dementia
- dc.subject.keyword Diet
- dc.subject.keyword Docosahexaenoic acid
- dc.subject.keyword Fatty acids
- dc.subject.keyword Lipidomics
- dc.title Plasma omega-3 fatty acids and risk for incident dementia in the UK biobank study: A closer look
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion