A novel mechanism for the prevention of transcription replication conflicts

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• dc.contributor.author Canal de Torres, Berta, 1988-
• dc.contributor.author Duch, Alba
• dc.contributor.author Posas Garriga, Francesc
• dc.contributor.author Nadal Clanchet, Eulàlia de
• dc.date.accessioned 2018-12-20T15:34:41Z
• dc.date.available 2018-12-20T15:34:41Z
• dc.date.issued 2018
• dc.description.abstract Transcription and replication complexes can coincide in space and time. Such coincidences may result in collisions that trigger genomic instability. The phosphorylation of Mrc1 by different signaling kinases is part of a general mechanism that serves to delay replication in response to different stresses that trigger a massive transcriptional response in S phase. This mechanism prevents Transcription-Replication Conflicts and maintains genomic integrity in response to unscheduled massive transcription during S phase.
• dc.description.sponsorship BC is a recipient of an FPI fellowship. The FP and EdN's laboratory is supported by grants from the Spanish Ministry of Economy and Competitiveness (BFU2015-64437-P and FEDER, BFU2014-52125-REDT, and BFU2014-51672-REDC to FP; BFU2017-85152-P and FEDER to EdN), the Catalan Government (2017 SGR 799), the Fundación Botín, and by the Banco Santander through its Santander Universities Global Division to FP. FP is a recipient of an ICREA Acadèmia (Generalitat de Catalunya). The department is supported by Unidad de Excelencia Maria de Maeztu, MDM-2014-0370.
• dc.format.mimetype application/pdf
• dc.identifier.citation Canal B, Duch A, Posas F, de Nadal E. A novel mechanism for the prevention of transcription replication conflicts. Mol Cell Oncol. 2018;5(3):e1451233. DOI: 10.1080/23723556.2018.1451233
• dc.identifier.doi http://dx.doi.org/10.1080/23723556.2018.1451233
• dc.identifier.issn 2372-3556
• dc.identifier.uri http://hdl.handle.net/10230/36164
• dc.language.iso eng
• dc.publisher Taylor & Francis
• dc.relation.ispartof Molecular & Cellular Oncology. 2018;5(3):e1451233
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-64437-P
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-52125-REDT
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-51672-REDC
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2017-85152-P
• dc.rights © 2018 Berta Canal, Alba Duch, Francesc Posas, and Eulàlia de Nadal. Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Cellular stress
• dc.subject.keyword Genomic instability
• dc.subject.keyword Mrc1
• dc.subject.keyword Signaling kinases
• dc.subject.keyword Transcription replication conflicts
• dc.title A novel mechanism for the prevention of transcription replication conflicts
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion