Pregnenolone can protect the brain from cannabis intoxication

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• dc.contributor.author Vallée, Monique
• dc.contributor.author Martín García, Elena, 1975-
• dc.contributor.author Maldonado, Rafael, 1961-
• dc.contributor.author Piazza, Pier Vincenzo
• dc.date.accessioned 2019-04-08T11:30:05Z
• dc.date.available 2019-04-08T11:30:05Z
• dc.date.issued 2014
• dc.description.abstract Pregnenolone is considered the inactive precursor of all steroid hormones, and its potential functional effects have been largely uninvestigated. The administration of the main active principle of Cannabis sativa (marijuana), Δ(9)-tetrahydrocannabinol (THC), substantially increases the synthesis of pregnenolone in the brain via activation of the type-1 cannabinoid (CB1) receptor. Pregnenolone then, acting as a signaling-specific inhibitor of the CB1 receptor, reduces several effects of THC. This negative feedback mediated by pregnenolone reveals a previously unknown paracrine/autocrine loop protecting the brain from CB1 receptor overactivation that could open an unforeseen approach for the treatment of cannabis intoxication and addiction.
• dc.description.sponsorship Supported by the EU-FP7 (REPROBESITY, HEALTH-F2-2008-223713, G.M.), the European Research Council (ENDOFOOD, ERC-2010-StG-260515, G.M.), the Agence Nationale pour la Recherche (contracts HICOMET and TIMMS, P.V.P.), the U.S. National Institutes of Health (NIH) (grants DA-03672, DA-003934, and DA-09789, R.A.R. and G.L.B., and RO1 DA003934 and KO5 DA021358, P.H.R.
• dc.format.mimetype application/pdf
• dc.identifier.citation Vallée M, Vitiello S, Bellocchio L, Hébert-Chatelain E, Monlezun S, Martin-Garcia E et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8. DOI: 10.1126/science.1243985
• dc.identifier.doi http://dx.doi.org/10.1126/science.1243985
• dc.identifier.issn 0036-8075
• dc.identifier.uri http://hdl.handle.net/10230/37066
• dc.language.iso eng
• dc.publisher American Association for the Advancement of Science (AAAS)
• dc.relation.ispartof Science. 2014 Jan 3;343(6166):94-8
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/223713
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/260515
• dc.rights This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on vol. 343, num. 6166, 2014, DOI: 10.1126/science.1243985
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Cervell -- Efectes de les drogues sobre
• dc.subject.other Cannabis
• dc.subject.other Cannabinoides
• dc.subject.other Pregnenolona
• dc.title Pregnenolone can protect the brain from cannabis intoxication
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion