Specific GATA factors act as conserved inducers of an endodermal-EMT
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- dc.contributor.author Campbell, Kiraca
- dc.contributor.author Whissell, Gavin, 1978-ca
- dc.contributor.author Franco-Marro, Xavierca
- dc.contributor.author Batlle Gómez, Eduardca
- dc.contributor.author Casanova, Jordica
- dc.date.accessioned 2015-07-15T06:58:01Z
- dc.date.available 2015-07-15T06:58:01Z
- dc.date.issued 2011ca
- dc.description.abstract The epithelial-to-mesenchymal transition (EMT) converts cells from static epithelial to migratory mesenchymal states (Hay, 1995). Here, we demonstrate that EMT in the Drosophila endoderm is dependent on the GATA-factor Serpent (Srp), and that Srp acts as a potent trigger for this transition when activated ectopically. We show that Srp affects endodermal-EMT through a downregulation of junctional dE-Cadherin (dE-Cad) protein, without a block in its transcription. Moreover, the relocalization of dE-Cad is achieved through the direct repression of crumbs (crb) by Srp. Finally, we show that hGATA-6, an ortholog of Srp, induces a similar transition in mammalian cells. Similar to Srp, hGATA-6 acts through the downregulation of junctional E-Cad, without blocking its transcription, and induces the repression of a Crumbs ortholog, crb2. Together, these results identify a set of GATA factors as a conserved alternative trigger to repress epithelial characteristics and confer migratory capabilities on epithelial cells in development and pathogenesis.
- dc.description.sponsorship This work has been supported by the Generalitat de Catalunya, the Spanish Ministerio de Ciencia e Innovacion (MICINN) and its Consolider-Ingenio 2010 program to J.C., X.F.-M., and E.B. We also acknowledge support from the Programa Juan de la Cierva (K.C.) and the European Research/nCouncil (ERC-FP7) (E.B.)
- dc.format.mimetype application/pdfca
- dc.identifier.citation Campbell K, Whissell G, Franch-Marro X, Batlle E, Casanova J. Specific GATA/nfactors act as conserved inducers of an endodermal-EMT. Dev Cell. 2011 Dec/n13; 21(6):1051-61. DOI: 10.1016/j.devcel.2011.10.005ca
- dc.identifier.doi http://dx.doi.org/10.1016/j.devcel.2011.10.005
- dc.identifier.issn 1534-5807ca
- dc.identifier.uri http://hdl.handle.net/10230/24599
- dc.language.iso engca
- dc.publisher Elsevierca
- dc.relation.ispartof Developmental Cell. 2011 Dec 13;21(6):1051-61
- dc.rights © Elsevier This is the published version of an article http://dx.doi.org/10.1016/j.devcel.2011.10.005 that appeared in the journal Developmental cell. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-licenseca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Drosòfila
- dc.subject.other Embriologia humana
- dc.subject.other Factors de transcripció
- dc.title Specific GATA factors act as conserved inducers of an endodermal-EMTca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca