Mapping the structural connectivity fingerprints of corticostriatal circuits in 
Huntington’s disease

Acero Pousa, Irene

Mapping the structural connectivity fingerprints of corticostriatal circuits in Huntington’s disease

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Citation

Acero Pousa, I. Mapping the structural connectivity fingerprints of corticostriatal circuits in Huntington’s disease. 2020. handle: http://hdl.handle.net/10230/46641

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Abstract

Huntington’s disease (HD) is a genetic neurodegenerative disease caused by a mutation in the HTT gene which involves a mixture of symptoms, including motor, cognitive and psychiatric deficits. However, there is a high degree of heterogeneity in the prominence and evolution of each type of symptom. The three main cortico-striatal circuits (motor, cognitive control and motivational) result affected by neurodegeneration, which could be one possible source of such interindividual differences among HD patients. The aim of this research is to characterize the structural connectivity of the three main cortico-striatal circuits in order to delineate specific neurodegeneration patterns that might underlay the different symptomatic profiles in HD.