The DREAM complex promotes gene body H2A.Z for target repression
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- dc.contributor.author Latorre, Isabelca
- dc.contributor.author Chesney, Michael A.ca
- dc.contributor.author Garrigues, Jacob M.ca
- dc.contributor.author Stempor, Przemyslawca
- dc.contributor.author Appert, Alexca
- dc.contributor.author Francesconi, Mirkoca
- dc.contributor.author Strome, Susanca
- dc.contributor.author Ahringer, Julieca
- dc.date.accessioned 2015-11-10T17:13:49Z
- dc.date.available 2015-11-10T17:13:49Z
- dc.date.issued 2015
- dc.description.abstract The DREAM (DP, Retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell cycle genes, but its mechanism of action is poorly understood. Here we show that Caenorhabditis elegans DREAM targets have an unusual pattern of high gene body HTZ-1/H2A.Z. In mutants of lin-35, the sole p130/Rb-like gene in C. elegans, DREAM targets have reduced gene body HTZ-1/H2A.Z and increased expression. Consistent with a repressive role for gene body H2A.Z, many DREAM targets are up-regulated in htz-1/ H2A.Z mutants. Our results indicate that the DREAM complex facilitates high gene body HTZ-1/H2A.Z, which plays a role in target gene repression.ca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Latorre I, Chesney MA, Garrigues JM, Stempor P, Appert A, Francesconi M et al. The DREAM complex promotes gene body H2A.Z for target repression. Genes & development. 2015; 29(5): 495-500. DOI 10.1101/gad.255810.114ca
- dc.identifier.doi http://dx.doi.org/10.1101/gad.255810.114
- dc.identifier.issn 0890-9369
- dc.identifier.uri http://hdl.handle.net/10230/25040
- dc.language.iso catca
- dc.publisher Cold Spring Harbor Laboratory Pressca
- dc.relation.ispartof Genes & development. 2015; 29(5): 495-500
- dc.rights © 2015 Latorre et al. This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
- dc.subject.keyword C. elegans
- dc.subject.keyword H2A.Z
- dc.subject.keyword Retinoblastoma/DREAM
- dc.subject.keyword Transcriptional repression
- dc.subject.other Histonesca
- dc.subject.other Proteïnes -- Metabolismeca
- dc.title The DREAM complex promotes gene body H2A.Z for target repressionca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca