The pathophysiology of axonal transport in alzheimer’s disease
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- dc.contributor.author Vicario Orri, Elena, 1989-ca
- dc.contributor.author Opazo, Carlos M.ca
- dc.contributor.author Muñoz López, Francisco José, 1964-ca
- dc.date.accessioned 2016-06-09T16:58:11Z
- dc.date.available 2016-06-09T16:58:11Z
- dc.date.issued 2015
- dc.description.abstract Neurons communicate in the nervous system by carrying out information along the length of their axons to finally transmit it at the synapse. Proper function of axons and axon terminals relies on the transport of proteins, organelles, vesicles, and other elements from the site of synthesis in the cell body. Conversely, neurotrophins secreted from axonal targets and other components at nerve terminals need to travel toward the cell body for clearance. Molecular motors, namely kinesins and dyneins, are responsible for the movement of these elements along cytoskeletal tracks. Given the challenging structure of neurons, axonal transport machinery plays a crucial role in maintaining neuronal viability and function, allowing the proper neurotransmitter release at the presynaptic ending. On this basis, failure of axonal transport has been proposed as a key player in the development and/or progression of neurodegenerative disorders such as Alzheimer's disease (AD). Increasing evidence suggests that amyloid-β peptide, a hallmark of AD, may disrupt axonal transport and in so doing, contribute to AD pathophysiology. Here we discuss the molecular mechanisms of axonal transport with specific emphasis on the possible relationship between defective axonal transport and AD.ca
- dc.description.sponsorship Supported by the Plan Estatal de I+D+i 2013-2016 and the ISCIII-Subdirección General de Evaluación y Fomento de la Investigación (Grants PI13/00408, and Red HERACLES RD12/0042/0014) and FEDER Funds; Generalitat de Catalunya (SGR09-1369); and Fundació la Marató de TV3 (100310). E.V is supported by a fellowship from Fundació La Caixa. Figures were produced using Servier Medical Art.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Vicario-Orri E, Opazo C, Muñoz FJ. The pathophysiology of axonal transport in alzheimer’s disease. Journal of Alzheimer's Disease. 2015;43(4):1097-113. DOI: 10.3233/JAD-141080ca
- dc.identifier.doi http://dx.doi.org/10.3233/JAD-141080
- dc.identifier.issn 1387-2877
- dc.identifier.uri http://hdl.handle.net/10230/26884
- dc.language.iso engca
- dc.publisher IOS Pressca
- dc.relation.ispartof Journal of Alzheimer's Disease. 2015;43(4):1097-113
- dc.relation.ispartof Alzheimer's disease
- dc.relation.ispartof Amyloid-β peptide
- dc.relation.ispartof Axon
- dc.relation.ispartof Fast axonal transport
- dc.relation.ispartof Molecular motors
- dc.rights The final publication is available at IOS Press through http://dx.doi.org/10.3233/JAD-141080ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Alzheimer, Malaltia d'ca
- dc.title The pathophysiology of axonal transport in alzheimer’s diseaseca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca