The dietary inflammatory index and chronic lymphocytic leukaemia in the MCC Spain Study
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- dc.contributor.author Flores, José Carlos
- dc.contributor.author Gracia Lavedan, Esther
- dc.contributor.author Romaguera Bosch, Dora
- dc.contributor.author Gimeno Vázquez, Eva
- dc.contributor.author Kogevinas, Manolis
- dc.contributor.author Castaño Vinyals, Gemma
- dc.contributor.author Casabonne, Delphine
- dc.date.accessioned 2020-06-16T07:06:49Z
- dc.date.available 2020-06-16T07:06:49Z
- dc.date.issued 2020
- dc.description.abstract Chronic inflammation plays a role in the development of chronic lymphocytic leukaemia (CLL), and diet might modulate chronic inflammation. This study aims to evaluate the association between the dietary inflammatory index (DII®) and CLL. A total of 366 CLL cases and 1643 controls of the Spanish multicase-control (MCC) Spain study were included. The inflammatory potential of the diet was assessed using the energy-adjusted dietary inflammatory index (E-DII) based on 30 items from a validated semi-quantitative food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models controlling for potential confounders. Overall, a modest, non-statistically significant, positive association was observed between CLL and E-DII scores (OR for a one-unit increase in E-DII: 1.05 (CI 95%: 0.99, 1.12), p-value = 0.09 and by tertiles: ORT2vsT1: 1.20 (CI 95%: 0.90, 1.59); OR T3vsT1: 1.21 (CI 95%: 0.90, 1.62), p trend = 0.21). These results were independent from disease severity (p-het: 0.70), time from diagnosis (p-het: 0.67) and CLL treatment received (p-het: 0.56). No interactions were detected. In conclusion, the consumption of a diet with high pro-inflammatory components was not significantly associated with CLL. Changes towards a more pro-inflammatory dietary pattern in younger generations not included here warrant future research.
- dc.format.mimetype application/pdf
- dc.identifier.citation Flores JC, Gracia-Lavedan E, Benavente Y, Amiano P, Romaguera D, Costas L, et al. The dietary inflammatory index and chronic lymphocytic leukaemia in the MCC Spain Study. Nutrients. 2019 Dec 23; 12(1):48. DOI: 10.3390/nu12010048
- dc.identifier.doi http://dx.doi.org/10.3390/nu12010048
- dc.identifier.issn 2072-6643
- dc.identifier.uri http://hdl.handle.net/10230/44984
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Nutrients. 2019 Dec 23;12(1):48
- dc.rights Copyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword MCC Spain study
- dc.subject.keyword Cancer
- dc.subject.keyword Case-control study
- dc.subject.keyword Chronic lymphocytic leukaemia
- dc.subject.keyword Dietary inflammatory index
- dc.subject.keyword Nutrition
- dc.title The dietary inflammatory index and chronic lymphocytic leukaemia in the MCC Spain Study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion