Automated method for small-animal PET image registration with intrinsic validation

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  • dc.contributor.author Pascau, Javier
  • dc.contributor.author Gispert López, Juan Domingo
  • dc.contributor.author Michaelides, Michael
  • dc.contributor.author Thanos, Panayotis K.
  • dc.contributor.author Volkow, Nora D.
  • dc.contributor.author Vaquero, Juan J.
  • dc.contributor.author Soto-Montenegro, Maria Luisa
  • dc.contributor.author Desco, Manuel
  • dc.date.accessioned 2019-07-03T07:57:29Z
  • dc.date.available 2019-07-03T07:57:29Z
  • dc.date.issued 2009
  • dc.description.abstract PURPOSE: We propose and compare different registration approaches to align small-animal PET studies and a procedure to validate the results by means of objective registration consistency measurements. PROCEDURES: We have applied a registration algorithm based on information theory, using different approaches to mask the reference image. The registration consistency allows for the detection of incorrect registrations. This methodology has been evaluated on a test dataset (FDG-PET rat brain images). RESULTS: The results show that a multiresolution two-step registration approach based on the use of the whole image at the low resolution step, while masking the brain at the high resolution step, provides the best robustness (87.5% registration success) and highest accuracy (0.67-mm average). CONCLUSIONS: The major advantages of our approach are minimal user interaction and automatic assessment of the registration error, avoiding visual inspection of the results, thus facilitating the accurate, objective, and rapid analysis of large groups of rodent PET images.
  • dc.description.sponsorship This work was supported by projects CIBER CB06/01/0079 (Ministerio de Sanidad y Consumo) and CDTEAM (CENIT program, Ministerio de Industria). Further support came from NIAAA Intramural Research Program (AA 11034 and AA07574, AA07611) and the US Department of Energy (DE-AC02-98CH10886)
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Pascau J, Gispert JD, Michaelides M, Thanos PK, Volkow ND, Vaquero JJ et al. Automated method for small-animal PET image registration with intrinsic validation. Mol Imaging Biol. 2009 Mar-Apr;11(2):107-13. DOI: 10.1007/s11307-008-0166-z
  • dc.identifier.doi http://dx.doi.org/10.1007/s11307-008-0166-z
  • dc.identifier.issn 1536-1632
  • dc.identifier.uri http://hdl.handle.net/10230/41922
  • dc.language.iso eng
  • dc.publisher Springer
  • dc.relation.ispartof Molecular Imaging and Biology. 2009 Mar-Apr;11(2):107-13
  • dc.rights © Springer. The final publication is available at Springer via http://dx.doi.org/10.1007/s11307-008-0166-z
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.other Imatges -- Processament -- Ensenyament assistit per ordinador
  • dc.subject.other Tomografia per emissió de positrons
  • dc.title Automated method for small-animal PET image registration with intrinsic validation
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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