In utero exposure to dioxins and dioxin-like compounds and anogenital distance in newborns and infants
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Vafeiadi, Marina, 1983-ca
- dc.contributor.author Agramunt, Silviaca
- dc.contributor.author Papadopoulou, Eleni, 1985-ca
- dc.contributor.author Besselink, Harrieca
- dc.contributor.author Mathianaki, Kleopatraca
- dc.contributor.author Karakosta, Polyxenica
- dc.contributor.author Spanaki, Arianaca
- dc.contributor.author Koutis, Antonisca
- dc.contributor.author Chatzi, Ledaca
- dc.contributor.author Vrijheid, Martineca
- dc.contributor.author Kogevinas, Manolisca
- dc.date.accessioned 2015-09-28T09:39:59Z
- dc.date.available 2015-09-28T09:39:59Z
- dc.date.issued 2013ca
- dc.description.abstract BACKGROUND: Anogenital distance in animals is used as a measure of fetal androgen action. Prenatal exposure to dioxins and dioxin-like compounds in rodents causes reproductive changes in male offspring and decreases anogenital distance. OBJECTIVE: We assessed whether in utero exposure to dioxins and dioxin-like compounds adversely influences anogenital distance in newborns and young children (median age, 16 months; range, 1-31 months) METHODS: We measured anogenital distance among participants of the "Rhea" mother-child cohort study in Crete and the Hospital del Mar (HMAR) cohort in Barcelona. Anogenital distance (AGD; anus to upper penis), anoscrotal distance (ASD; anus to scrotum), and penis width (PW) were measured in 119 newborn and 239 young boys; anoclitoral (ACD; anus to clitoris) and anofourchetal distance (AFD; anus to fourchette) were measured in 118 newborn and 223 young girls. We estimated plasma dioxin-like activity in maternal blood samples collected at delivery with the Dioxin-Responsive Chemically Activated LUciferase eXpression (DR CALUX®) bioassay. RESULTS: Anogenital distances were sexually dimorphic, being longer in males than females. Plasma dioxin-like activity was negatively associated with AGD in male newborns. The estimated change in AGD per 10 pg CALUX®-toxic equivalent/g lipid increase was -0.44 mm (95% CI: -0.80, -0.08) after adjusting for confounders. Negative but smaller and nonsignificant associations were observed for AGD in young boys. No associations were found in girls. CONCLUSIONS: Male infants may be susceptible to endocrine-disrupting effects of dioxins. Our findings are consistent with the experimental animal evidence used by the Food and Agriculture Organization/World Health Organization to set recommendations for human dioxin intake.
- dc.description.sponsorship This study was partly funded by FP6 and FP7 European Union grants (contract number FOOD-CT-2005-016320 and 241604 respectively)
- dc.format.mimetype application/pdfca
- dc.identifier.citation Vafeiadi M, Agramunt S, Papadopoulou E, Besselink H, Mathianaki K, Karakosta P et al. In utero exposure to dioxins and dioxin-like compounds and anogenital distance in newborns and infants. Environ Health Perspect. 2013 Jan;121(1):125-30. DOI: 10.1289/ehp.1205221ca
- dc.identifier.doi http://dx.doi.org/10.1289/ehp.1205221
- dc.identifier.issn 0091-6765ca
- dc.identifier.uri http://hdl.handle.net/10230/24767
- dc.language.iso engca
- dc.publisher National Institute of Environmental Health Sciences (NIEHS)ca
- dc.relation.ispartof Environmental Health Perspectives. 2013 Jan;121(1):125-30
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP6/016320
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/241604
- dc.rights Reproduced with permission from Environmental Health Perspectivesca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Dioxines -- Toxicologia
- dc.subject.other Contaminació
- dc.subject.other Aparell genital masculí
- dc.title In utero exposure to dioxins and dioxin-like compounds and anogenital distance in newborns and infantsca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca