Detection of serrated lesions in proximal colon by simulated sigmoidoscopy vs faecal immunochemical testing in a multicentre, pragmatic, randomised controlled trial
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- dc.contributor.author Carot, Laura
- dc.contributor.author Castells, Antoni
- dc.contributor.author Hernández Rodríguez, Cristina
- dc.contributor.author Alvarez-Urturi, Ana Cristina
- dc.contributor.author Balaguer, Francesc
- dc.contributor.author Lanas, Angel
- dc.contributor.author Cubiella, Joaquı́n
- dc.contributor.author Tasende, Jose D.
- dc.contributor.author Jover, Rodrigo
- dc.contributor.author Hernandez, Vicent
- dc.contributor.author Carballo, Fernando
- dc.contributor.author Bujanda, Luis
- dc.contributor.author Quintero, Enrique
- dc.contributor.author Andreu García, Montserrat
- dc.contributor.author Bessa Caserras, Xavier
- dc.contributor.author ColonPrev study
- dc.date.accessioned 2019-07-19T07:49:09Z
- dc.date.available 2019-07-19T07:49:09Z
- dc.date.issued 2018
- dc.description.abstract BACKGROUND: The diagnostic yield of the faecal immunochemical test and sigmoidoscopy in detecting proximal serrated polyps in a colorectal cancer screening programme has not been fully assessed. AIM: We determined the detection rate of proximal serrated polyps by simulated sigmoidoscopy and faecal immunochemical test compared with total colonoscopy in a population-based, multicentre, nationwide, randomised controlled trial (ColonPrev study). METHODS: Sigmoidoscopy yield was simulated based on the UK-Flexible Sigmoidoscopy Trial for total colonoscopy referral. Definitions were: proximal serrated polyp (proximal serrated polyp): sessile serrated polyp or hyperplastic polyp of any size and proximal at-risk serrated polyp (at-risk proximal serrated polyp): sessile serrated polyp of any size or hyperplastic polyp ≥ 10 mm, both located proximally to the splenic flexure. RESULTS: A total of 10,611 individuals underwent faecal immunochemical test and 5059 underwent total colonoscopy and were evaluated by simulated sigmoidoscopy. Sigmoidoscopy and faecal immunochemical test were less accurate in detecting proximal serrated polyps (odds ratio: 0.13; 95% confidence interval: 0.10-0.18 and 0.13; 0.09-0.18, p < 0.0001, respectively). Both tests were inferior to colonoscopy in detecting at-risk proximal serrated polyps, and sigmoidoscopy was inferior to faecal immunochemical test in detecting these lesions (odds ratio: 0.17; 95% confidence interval: 0.10-0.30 and 0.25; 0.17-0.37, p < 0.0001, respectively). CONCLUSION: Sigmoidoscopy and faecal immunochemical test are less accurate in detecting proximal serrated polyps than colonoscopy, particularly in women.
- dc.format.mimetype application/pdf
- dc.identifier.citation Carot L, Castells A, Hernández C, Alvarez-Urturi C, Balaguer F, Lanas A. et al. Detection of serrated lesions in proximal colon by simulated sigmoidoscopy vs faecal immunochemical testing in a multicentre, pragmatic, randomised controlled trial. United European Gastroenterol J. 2018 Dec;6(10):1527-1537. DOI: 10.1177/2050640618804722
- dc.identifier.doi http://dx.doi.org/10.1177/2050640618804722
- dc.identifier.issn 2050-6406
- dc.identifier.uri http://hdl.handle.net/10230/42061
- dc.language.iso eng
- dc.publisher SAGE Publications
- dc.relation.ispartof United European Gastroenterol Journal. 2018 Dec;6(10):1527-1537
- dc.rights Carot L, Castells A, Hernández C, Alvarez-Urturi C, Balaguer F, Lanas A. et al. Detection of serrated lesions in proximal colon by simulated sigmoidoscopy vs faecal immunochemical testing in a multicentre, pragmatic, randomised controlled trial. United European Gastroenterol J. 2018 Dec;6(10):1527-1537. Copyright © 2018 . DOI: 10.1177/2050640618804722.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Serrated polyps
- dc.subject.keyword Colorectal cancer screening
- dc.subject.keyword Faecal immunochemical test
- dc.subject.keyword Sigmoidoscopy
- dc.title Detection of serrated lesions in proximal colon by simulated sigmoidoscopy vs faecal immunochemical testing in a multicentre, pragmatic, randomised controlled trial
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion