The dominance effect of the adaptive transposable element insertion Bari-Jheh depends on the genetic background

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• dc.contributor.author González Pérez, Josefa, 1973-
• dc.contributor.author Guio, Lain
• dc.date.accessioned 2024-01-22T06:49:21Z
• dc.date.available 2024-01-22T06:49:21Z
• dc.date.issued 2015
• dc.description.abstract Although adaptive mutations are often considered to be dominant, it has been recently shown that a substantial proportion of adaptive mutations should display heterozygote advantage. In this work, we take advantage of a recently characterized transposable element insertion mediating oxidative stress response in Drosophila melanogaster to test the dominance effect of an adaptive mutation. The comparison of the survival curves of heterozygous and the two corresponding homozygous flies indicated that the dominance effect of Bari-Jheh depends on the genetic background. Both in homozygous and in heterozygous flies, Bari-Jheh was associated with upregulation of Jheh1 (Juvenile Hormone Epoxyde Hydrolase 1) and/or Jheh2 genes. Our results add to the limited number of studies in which the dominance effect of adaptive mutations has been empirically estimated and highlights the complexity of their inheritance.
• dc.description.sponsorship The authors thank Diamantis Sellis and Maite G. Barrón for helpful comments. L.G. is a FI/DGR fellow (2012FI-B-00676). J.G. is a Ramón y Cajal fellow (RYC-2010-07306). This work was supported by grants from the European Commission (Marie Curie CIG PCIG-GA-2011-293860) and from the Spanish Government (Fundamental Research Projects Grant BFU-2011-24397).
• dc.format.mimetype application/pdf
• dc.identifier.citation Guio L, González J. The dominance effect of the adaptive transposable element insertion Bari-Jheh depends on the genetic background. Genome Biology and Evolution. 2015 May;7(5):1260-6. DOI: 10.1093/gbe/evv071
• dc.identifier.doi http://dx.doi.org/10.1093/gbe/evv071
• dc.identifier.issn 1759-6653
• dc.identifier.uri http://hdl.handle.net/10230/58771
• dc.language.iso eng
• dc.publisher Oxford University Press
• dc.relation.ispartof Genome Biology and Evolution. 2015 May;7(5):1260-6
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/293860
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-24397
• dc.rights © The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Adaptive mutation
• dc.subject.keyword Selective sweep
• dc.subject.keyword Heterozygote advantage
• dc.subject.keyword Xidative stress
• dc.subject.keyword Drosophila
• dc.subject.keyword Dominance effect
• dc.title The dominance effect of the adaptive transposable element insertion Bari-Jheh depends on the genetic background
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion