Maternal preconception occupational exposure to cleaning products and disinfectants and offspring asthma

Tjalvin, Gro; Svanes, Øistein; Igland, Jannicke; Bertelsen, Randi Jacobsen; Benediktsdóttir, Bryndís; Dharmage, Shyamali C.; Forsberg, Bertil; Holm, Mathias; Janson, Christer; Jõgi, Nils Oskar; Johannessen, Ane; Malinovschi, Andrei; Pape, Kathrine; Gómez Real, Francisco; Sigsgaard, Torben; Torén, Kjell; Vindenes, Hilde Kristin; Zock, Jan-Paul; Schlünssen, Vivi; Svanes, Cecilie

Maternal preconception occupational exposure to cleaning products and disinfectants and offspring asthma

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dc.contributor.author Tjalvin, Gro
dc.contributor.author Svanes, Øistein
dc.contributor.author Igland, Jannicke
dc.contributor.author Bertelsen, Randi Jacobsen
dc.contributor.author Benediktsdóttir, Bryndís
dc.contributor.author Dharmage, Shyamali C.
dc.contributor.author Forsberg, Bertil
dc.contributor.author Holm, Mathias
dc.contributor.author Janson, Christer
dc.contributor.author Jõgi, Nils Oskar
dc.contributor.author Johannessen, Ane
dc.contributor.author Malinovschi, Andrei
dc.contributor.author Pape, Kathrine
dc.contributor.author Gómez Real, Francisco
dc.contributor.author Sigsgaard, Torben
dc.contributor.author Torén, Kjell
dc.contributor.author Vindenes, Hilde Kristin
dc.contributor.author Zock, Jan-Paul
dc.contributor.author Schlünssen, Vivi
dc.contributor.author Svanes, Cecilie
dc.date.accessioned 2022-05-25T05:35:23Z
dc.date.available 2022-05-25T05:35:23Z
dc.date.issued 2022
dc.description.abstract Background: Emerging research suggests health effects in offspring after parental chemical exposures before conception. Many future mothers are exposed to potent chemicals at work, but potential offspring health effects are hardly investigated. Objective: We sought to investigate childhood asthma in relation to mother's occupational exposure to cleaning products and disinfectants before conception. Methods: The multicenter Respiratory Health In Northern Europe/Respiratory Health In Northern Europe, Spain and Australia generation study investigated asthma and wheeze starting at age less than 10 years in 3318 mother-offspring pairs. From an asthma-specific Job-Exposure Matrix and mothers' occupational history, we defined maternal occupational exposure to indoor cleaning agents (cleaning products/detergents and disinfectants) starting before conception, in the 2-year period around conception and pregnancy, or after birth. Never-employed mothers were excluded. Exposed groups include cleaners, health care workers, cooks, and so forth. Associations were analyzed using mixed-effects logistic regression and ordinary logistic regression with clustered robust SEs and adjustment for maternal education. Results: Maternal occupational exposure to indoor cleaning starting preconception and continuing (n = 610) was associated with offspring's childhood asthma: odds ratio 1.56 (95% CI, 1.05-2.31), childhood asthma with nasal allergies: 1.77 (1.13-2.77), and childhood wheeze and/or asthma: 1.71 (95% CI, 1.19-2.44). Exposure starting around conception and pregnancy (n = 77) was associated with increased childhood wheeze and/or asthma: 2.25 (95% CI, 1.03-4.91). Exposure starting after birth was not associated with asthma outcomes (1.13 [95% CI, 0.71-1.80], 1.15 [95% CI, 0.67-1.97], 1.08 [95% CI, 0.69-1.67]). Conclusions: Mother's occupational exposure to indoor cleaning agents starting before conception, or around conception and pregnancy, was associated with more childhood asthma and wheeze in offspring. Considering potential implications for vast numbers of women in childbearing age using cleaning agents, and their children, further research is imperative.
dc.format.mimetype application/pdf
dc.identifier.citation Tjalvin G, Svanes Ø, Igland J, Bertelsen RJ, Benediktsdóttir B, Dharmage S, Forsberg B, Holm M, Janson C, Jõgi NO, Johannessen A, Malinovschi A, Pape K, Real FG, Sigsgaard T, Torén K, Vindenes HK, Zock JP, Schlünssen V, Svanes C. Maternal preconception occupational exposure to cleaning products and disinfectants and offspring asthma. J Allergy Clin Immunol. 2022 Jan;149(1):422-31.e5. DOI: 10.1016/j.jaci.2021.08.025
dc.identifier.doi http://dx.doi.org/10.1016/j.jaci.2021.08.025
dc.identifier.issn 0091-6749
dc.identifier.uri http://hdl.handle.net/10230/53240
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof J Allergy Clin Immunol. 2022 Jan;149(1):422-31.e5
dc.rights © 2021 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY-NCND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keyword Job-Exposure Matrix (JEM)
dc.subject.keyword Occupational exposures
dc.subject.keyword RHINESSA
dc.subject.keyword Childhood asthma
dc.subject.keyword Cleaning products
dc.subject.keyword Disinfectants
dc.subject.keyword Generation study
dc.subject.keyword Mother
dc.subject.keyword Preconception exposures
dc.title Maternal preconception occupational exposure to cleaning products and disinfectants and offspring asthma
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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