Vulnerability to addiction
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- dc.contributor.author Maldonado, Rafael, 1961-
- dc.contributor.author Calvé Pérez, Pablo, 1993-
- dc.contributor.author García Blanco, Alejandra
- dc.contributor.author Domingo Rodriguez, Laura, 1992-
- dc.contributor.author Senabre, Eric
- dc.contributor.author Martín García, Elena, 1975-
- dc.date.accessioned 2021-11-17T07:38:32Z
- dc.date.issued 2021
- dc.description.abstract Addiction is a chronic brain disease that has dramatic health and socioeconomic consequences worldwide. Multiple approaches have been used for decades to clarify the neurobiological basis of this disease and to identify novel potential treatments. This review summarizes the main brain networks involved in the vulnerability to addiction and specific innovative technological approaches to investigate these neural circuits. First, the evolution of the definition of addiction across the Diagnostic and Statistical Manual of Mental Disorders (DSM) is revised. We next discuss several innovative experimental techniques that, combined with behavioral approaches, have allowed recent critical advances in understanding the neural circuits involved in addiction, including DREADDs, calcium imaging, and electrophysiology. All these techniques have been used to investigate specific neural circuits involved in vulnerability to addiction and have been extremely useful to clarify the neurobiological basis of each specific component of the addictive process. These novel tools targeting specific brain regions are of great interest to further understand the different aspects of this complex disease. This article is part of the special issue on 'Vulnerabilities to Substance Abuse.'.
- dc.description.sponsorship This work was supported by the Spanish Ministerio de Economía y Competitividad-MINECO (#SAF2017-84060-R-AEI/FEDER-UE), the Spanish Instituto de Salud Carlos III, RETICS-RTA (#RD12/0028/0023), the Generalitat de Catalunya, AGAUR (#2017-SGR-669), ICREA-Acadèmia (#2015) and the Spanish Ministerio de Sanidad, Servicios Sociales e Igualdad, Plan NAcional Sobre Drogas of the Spanish Ministry of Health (#PNSD-2017I068) to R.M., Fundació La Marató-TV3 (#2016/20-30) and Plan NAcional Sobre Drogas of the Spanish Ministry of Health (#PNSD-2019I006) to E.M-G. Figures are created with BioRender.com.
- dc.format.mimetype application/pdf
- dc.identifier.citation Maldonado R, Calvé P, García-Blanco A, Domingo-Rodriguez L, Senabre E, Martín-García E. Vulnerability to addiction. Neuropharmacology. 2021;186:108466. DOI: 10.1016/j.neuropharm.2021.108466
- dc.identifier.doi http://dx.doi.org/10.1016/j.neuropharm.2021.108466
- dc.identifier.issn 0028-3908
- dc.identifier.uri http://hdl.handle.net/10230/48998
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Neuropharmacology. 2021;186:108466
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/SAF2017-84060-R
- dc.rights © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Addiction
- dc.subject.keyword Calcium imaging
- dc.subject.keyword DREADD
- dc.subject.keyword DSM-5
- dc.subject.keyword Electrophysiology
- dc.subject.keyword Inhibitory control
- dc.subject.keyword Therapeutic approach
- dc.title Vulnerability to addiction
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion