Modulation of the endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans

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  • dc.contributor.author Fagundo, Ana B.ca
  • dc.contributor.author Torre Fornell, Rafael de laca
  • dc.contributor.author Jiménez Murcia, Susanaca
  • dc.contributor.author Agüera, Zaidaca
  • dc.contributor.author Pastor, Antonioca
  • dc.contributor.author Casanueva, Felipe F.ca
  • dc.contributor.author Granero, Roserca
  • dc.contributor.author Baños, Rosa M.ca
  • dc.contributor.author Botella, Cristinaca
  • dc.contributor.author de Pino Gutiárrez, Amparoca
  • dc.contributor.author Fernández Real, Jose M.ca
  • dc.contributor.author Fernández García, José C.ca
  • dc.contributor.author Frühbeck, Gemaca
  • dc.contributor.author Gómez Ambrosi, Javierca
  • dc.contributor.author Menchón, José M.ca
  • dc.contributor.author Moragrega, Inésca
  • dc.contributor.author Rodríguez, Roserca
  • dc.contributor.author Tárrega, Saloméca
  • dc.contributor.author Tinahones Madueño, Francisco Joséca
  • dc.contributor.author Fernández Aranda, Fernandoca
  • dc.date.accessioned 2015-05-13T10:42:08Z
  • dc.date.available 2015-05-13T10:42:08Z
  • dc.date.issued 2013ca
  • dc.description.abstract Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive impairments. However, to date, no published reports establish the relationship between endocannabinoids, as biomarkers of the cannabinoid neurotransmission system, and executive functioning in humans. The aim of the present study was to explore the association between circulating levels of plasma endocannabinoids N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) and executive functions (decision making, response inhibition and cognitive flexibility) in healthy subjects. One hundred and fifty seven subjects were included and assessed with the Wisconsin Card Sorting Test; Stroop Color and Word Test; and Iowa Gambling Task. All participants were female, aged between 18 and 60 years and spoke Spanish as their first language. Results showed a negative correlation between 2-AG and cognitive flexibility performance (r = −.37; p<.05). A positive correlation was found between AEA concentrations and both cognitive flexibility (r = .59; p<.05) and decision making performance (r = .23; P<.05). There was no significant correlation between either 2-AG (r = −.17) or AEA (r = −.08) concentrations and inhibition response. These results show, in humans, a relevant modulation of the endocannabinoid system on prefrontal-dependent cognitive functioning. The present study might have significant implications for the underlying executive alterations described in some psychiatric disorders currently associated with endocannabinoids deregulation (namely drug abuse/dependence, depression, obesity and eating disorders). Understanding the neurobiology of their dysexecutive profile might certainly contribute to the development of new treatments and pharmacological approaches.en
  • dc.description.sponsorship Financial support was received from Fondo de Investigación Sanitaria - FIS (PI081714; PI11/210) and AGAUR (2009SGR1554, 2009SGR718). Ministerio de Ciencia e Innovación Subprograma Juan de la Cierva (JCI-2011-09248). CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and CIBER Salud Mental (CIBERsam), are an initiative of ISCIIen
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Fagundo AB, de la Torre R, Jiménez-Murcia S, Aguera Z, Pastor A, Casanueva FF et al. Modulation of the endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humans. PLoS ONE. 2013;8(6):e66387. DOI: 10.1371/journal.pone.0066387ca
  • dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0066387
  • dc.identifier.issn 1932-6203ca
  • dc.identifier.uri http://hdl.handle.net/10230/23574
  • dc.language.iso engca
  • dc.publisher Public Library of Science (PLoS)ca
  • dc.relation.ispartof PLoS ONE. 2013;8(6):e66387
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/JCI2011-09248
  • dc.rights © 2013 Fagundo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.subject.other Cannabinoides -- Efectes fisiològicsca
  • dc.subject.other Cannabinoides -- Receptorsca
  • dc.title Modulation of the endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on executive functions in humansen
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca

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