Hippo signaling controls cell cycle and restricts cell plasticity in planarians
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- dc.contributor.author de Sousa, Nídia
- dc.contributor.author Rodríguez Esteban, Gustavo
- dc.contributor.author Rojo-Laguna, Jose Ignacio
- dc.contributor.author Saló, Emili
- dc.contributor.author Adell, Teresa
- dc.date.accessioned 2019-12-03T07:58:03Z
- dc.date.available 2019-12-03T07:58:03Z
- dc.date.issued 2018
- dc.description.abstract The Hippo pathway plays a key role in regulating cell turnover in adult tissues, and abnormalities in this pathway are consistently associated with human cancers. Hippo was initially implicated in the control of cell proliferation and death, and its inhibition is linked to the expansion of stem cells and progenitors, leading to larger organ size and tumor formation. To understand the mechanism by which Hippo directs cell renewal and promotes stemness, we studied its function in planarians. These stem cell-based organisms are ideal models for the analysis of the complex cellular events underlying tissue renewal in the whole organism. hippo RNA interference (RNAi) in planarians decreased apoptotic cell death, induced cell cycle arrest, and could promote the dedifferentiation of postmitotic cells. hippo RNAi resulted in extensive undifferentiated areas and overgrowths, with no effect on body size or cell number. We propose an essential role for hippo in controlling cell cycle, restricting cell plasticity, and thereby preventing tumoral transformation.
- dc.description.sponsorship Universitat de Barcelona (APIF fellowship). Received by NdS. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Ministerio de educación y ciencia (grant number BFU2017-83755-P and BFU2014-56055-P). Received by ES and TA. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. AGAUR (Generalitat de Catalunya) (grant number 2009SGR1018). Received by ES. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
- dc.format.mimetype application/pdf
- dc.identifier.citation de Sousa N, Rodríguez-Esteban G, Rojo-Laguna JI, Saló E, Adell T. Hippo signaling controls cell cycle and restricts cell plasticity in planarians. PLoS Biol. 2018;16(1):e2002399. DOI: 10.1371/journal.pbio.2002399
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pbio.2002399
- dc.identifier.issn 1544-9173
- dc.identifier.uri http://hdl.handle.net/10230/43062
- dc.language.iso eng
- dc.publisher Public Library of Science (PLoS)
- dc.relation.ispartof PLOS Biology. 2018;16(1):e2002399
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-83755-P
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-56055-P
- dc.rights © 2018 de Sousa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword RNA interference
- dc.subject.keyword Planarians
- dc.subject.keyword Immunostaining
- dc.subject.keyword Cell differentiation
- dc.subject.keyword Apoptosis
- dc.subject.keyword Cell cycle and cell division
- dc.subject.keyword Fluorescent in situ hybridization
- dc.subject.keyword DAPI staining
- dc.title Hippo signaling controls cell cycle and restricts cell plasticity in planarians
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion