Association between serum copper levels and risk of cardiovascular disease: A nested case-control study in the PREDIMED trial

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• dc.contributor.author Muñoz-Bravo, Carlos
• dc.contributor.author Olmedo, Pablo
• dc.contributor.author Gil, Fernando
• dc.contributor.author Ruiz-Canela, Miguel
• dc.contributor.author Martínez-González, Miguel Ángel, 1957-
• dc.contributor.author Martínez, María Ángeles
• dc.contributor.author Babio, Nancy
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Val, José Luis del
• dc.contributor.author Corella, Dolores
• dc.contributor.author Sorlí, José Vicente
• dc.contributor.author Ros, Emilio
• dc.contributor.author Fiol, Miquel
• dc.contributor.author Estruch, Ramón
• dc.contributor.author Santos Lozano, José Manuel
• dc.contributor.author Arós, Fernando
• dc.contributor.author Serra Majem, Lluís
• dc.contributor.author Pintó Sala, Xavier
• dc.contributor.author Gómez Gracia, Enrique
• dc.contributor.author Gutiérrez Bedmar, Mario
• dc.date.accessioned 2024-05-30T05:43:53Z
• dc.date.available 2024-05-30T05:43:53Z
• dc.date.issued 2023
• dc.description.abstract Background and aim: Certain trace elements have been associated with increased cardiovascular risk. The aim of this study was to evaluate the association between serum copper (S-Cu) levels and the risk of a first event of cardiovascular disease (CVD) in a population of older adults with high cardiovascular risk. Methods and results: We conducted a case-control study nested within the PREDIMED trial. During a median follow-up of 4.8 years, a total of 207 incident cases diagnosed with CVD were matched for sex, age, and intervention group with 436 controls. Personal interviews, reviews of medical records, and validated questionnaires were used to assess known CVD risk factors. Biological serum samples were collected annually. Inductively coupled plasma mass spectrometry analysis was used to determine S-Cu levels. Adjusted odds ratios were calculated using multivariate conditional logistic regression models. All participants had S-Cu levels within the reference values, 750 μg/L to 1450 μg/L. Among men, but not among women, the mean S-Cu concentration was higher in cases 1014.1 μg/L than in controls 959.3 μg/L; (p = 0.004). In men, the multivariable-adjusted odds ratio for CVD was 2.36 (95% CI 1.07-5.20 for the comparison of the highest vs. the lowest quartile; p for trend = 0.02), in women, it was 0.43 (95% CI 0.11-1.70; p for trend = 0.165). Conclusion: In older Spanish men with high cardiovascular risk, a significant association was observed between high S-Cu levels, but still within the reference values, and an increased risk of a first event of CVD. Our findings suggest a sex difference in CVD risk and S-Cu levels. To confirm this relationship and to analyze the differences observed between men and women, further studies are needed.
• dc.description.sponsorship This research was funded by the official funding agency for biomedical research of the Spanish government, Instituto de Salud Carlos III (ISCIII), through grants provided to research networks specifically developed for the trial (RTIC G03/140; RTIC RD 06/0045 “PREDIMED”), and JR14/00008, and through Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), and by grants from Centro Nacional de Investigaciones Cardiovasculares (CNIC06/2007), the Fondo de Investigación Sanitaria–Fondo Europeo de Desarrollo Regional (Proyecto de Investigación (PI04-2239, PI05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, P11/02505 and PI13/00462), the Ministerio de Ciencia e Innovación (Recursos y teconologia agroalimentarias (AGL)-2009-13906-C02 and AGL2010-22319-C03 and AGL2013-49083C3-1-R), the Ministerio de Economía y Competitividad-Fondos FEDER-Instituto de Salud Carlos III (UNGR15-CE-3380), the Fundación Mapfre 2010, the Consejería de Salud de la Junta de Andalucía (PI0105/2007), the Public Health Division of the Department of Health of the Autonomous Government of Catalonia, the Generalitat Valenciana (Generalitat Valenciana Ayuda Complementatia GVACOMP) 06109, GVACOMP2010-181, GVACOMP2011-151), Conselleria de Sanitat y AP; Atención Primaria (CS) 2010-AP-111, and CS2011-AP-042), Regional Government of Navarra (P27/2011), and Centre Català de la Nutrició de l'Institut d'Estudis Catalans. Hojiblanca and Patrimonio Communal Olivarero donated extra-virgin olive oil; the California Walnut Commission donated walnuts; Borges donated almonds; La Morella Nuts donated hazelnuts.
• dc.format.mimetype application/pdf
• dc.identifier.citation Muñoz-Bravo C, Olmedo P, Gil F, Ruiz-Canela M, Martínez-González MA, Martínez MÁ, et al. Association between serum copper levels and risk of cardiovascular disease: A nested case-control study in the PREDIMED trial. Nutr Metab Cardiovasc Dis. 2023 Nov;33(11):2199-208. DOI: 10.1016/j.numecd.2023.07.008
• dc.identifier.doi http://dx.doi.org/10.1016/j.numecd.2023.07.008
• dc.identifier.issn 0939-4753
• dc.identifier.uri http://hdl.handle.net/10230/60288
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Nutr Metab Cardiovasc Dis. 2023 Nov;33(11):2199-208
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2009-13906-C02
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2010-22319-C03
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/AGL2013-49083C3-1-R
• dc.rights © 2023 The Authors. Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Cardiovascular diseases
• dc.subject.keyword Infarction
• dc.subject.keyword PREDIMED
• dc.subject.keyword Serum copper
• dc.subject.keyword Stroke
• dc.subject.keyword Trace elements
• dc.title Association between serum copper levels and risk of cardiovascular disease: A nested case-control study in the PREDIMED trial
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion