Worldwide patterns of genomic variation and admixture in gray wolves

Fan, Zhenxin; Silva, Pedro; Gronau, Ilan; Wang, Shuoguo; Serres Armero, Aitor, 1992-; Schweizer, Rena M.; Ramírez, Oscar; Pollinger, John; Galaverni, Marco; Ortega Del-Vecchyo, Diego; Du, Lianming; Zhang, Wenping; Zhang, Zhihe; Xing, Jinchuan; Vilà, Carles; Marquès i Bonet, Tomàs, 1975-; Godinho, Raquel; Yue, Bisong; Wayne, Robert K.

Worldwide patterns of genomic variation and admixture in gray wolves

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dc.contributor.author Fan, Zhenxinca
dc.contributor.author Silva, Pedroca
dc.contributor.author Gronau, Ilanca
dc.contributor.author Wang, Shuoguoca
dc.contributor.author Serres Armero, Aitor, 1992-ca
dc.contributor.author Schweizer, Rena M.ca
dc.contributor.author Ramírez, Oscarca
dc.contributor.author Pollinger, Johnca
dc.contributor.author Galaverni, Marcoca
dc.contributor.author Ortega Del-Vecchyo, Diegoca
dc.contributor.author Du, Lianmingca
dc.contributor.author Zhang, Wenpingca
dc.contributor.author Zhang, Zhiheca
dc.contributor.author Xing, Jinchuanca
dc.contributor.author Vilà, Carlesca
dc.contributor.author Marquès i Bonet, Tomàs, 1975-ca
dc.contributor.author Godinho, Raquelca
dc.contributor.author Yue, Bisongca
dc.contributor.author Wayne, Robert K.ca
dc.date.accessioned 2016-03-29T12:59:46Z
dc.date.available 2016-08-01T02:00:04Z
dc.date.issued 2016
dc.description.abstract The gray wolf (Canis lupus) is a widely distributed top predator and ancestor of the domestic dog. To address questions about wolf relationships to each other and dogs, we assembled and analyzed a data set of 34 canine genomes. The divergence between New and Old World wolves is the earliest branching event and is followed by the divergence of Old World wolves and dogs, confirming that the dog was domesticated in the Old World. However, no single wolf population is more closely related to dogs, supporting the hypothesis that dogs were derived from an extinct wolf population. All extant wolves have a surprisingly recent common ancestry and experienced a dramatic population decline beginning at least ∼30 thousand years ago (kya). We suggest this crisis was related to the colonization of Eurasia by modern human hunter-gatherers, who competed with wolves for limited prey but also domesticated them, leading to a compensatory population expansion of dogs. We found extensive admixture between dogs and wolves, with up to 25% of Eurasian wolf genomes showing signs of dog ancestry. Dogs have influenced the recent history of wolves through admixture and vice versa, potentially enhancing adaptation. Simple scenarios of dog domestication are confounded by admixture, and studies that do not take admixture into account with specific demographic models are problematic.ca
dc.description.sponsorship This work was supported by National Science Foundation (NSF) grant EF-1021397 (R.K.W., R.M.S.), the National Key Technology R&D Program of China 2012BAC01B06 (Z.F., B.S.Y.), ICREA, EMBO YIP 2013 and MICINN BFU2014-55090-P (T.M.B.), National Human Genome Research Institute (NHGRI) grant R00HG005846 (J.X.), UC MEXUS-CONACYT doctoral fellowship 213627 (D.O.D.V.), the Chengdu Giant Panda Breeding Research Foundation CPF-yan-2012-10 (W.Z., Z.Z.), and the grant PRIC from Fundació Barcelona Zoo and Ajuntament de Barcelona (O.R.)
dc.format.mimetype application/pdfca
dc.identifier.citation Fan Z, Silva P, Gronau I, Wang S, Armero AS, Schweizer RM et al. Worldwide patterns of genomic variation and admixture in gray wolves. Genome Research. 2016; 26(2): 163-173. DOI 10.1101/gr.197517.115ca
dc.identifier.doi http://dx.doi.org/10.1101/gr.197517.115
dc.identifier.issn 1088-9051
dc.identifier.uri http://hdl.handle.net/10230/26027
dc.language.iso engca
dc.publisher Cold Spring Harbor Laboratory Press (CSHL Press)ca
dc.relation.ispartof Genome Research. 2016; 26(2): 163-173
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-55090-P
dc.rights © 2016 Fan et al. This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/ca
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/ca
dc.subject.other Genètica animalca
dc.title Worldwide patterns of genomic variation and admixture in gray wolvesca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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