Association between polyphenol intake and gastric cancer risk by anatomic and histologic subtypes: MCC-Spain
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- dc.contributor.author Rubín-García, María
- dc.contributor.author Vitelli Storelli, Facundo
- dc.contributor.author Molina, Antonio J.
- dc.contributor.author Zamora-Ros, Raúl
- dc.contributor.author Aragonés, Núria
- dc.contributor.author Ardanaz Aicua, Eva
- dc.contributor.author Castaño Vinyals, Gemma
- dc.contributor.author Obón-Santacana, Mireia
- dc.contributor.author Gómez-Acebo, Inés
- dc.contributor.author Molina-Barceló, Ana
- dc.contributor.author Fernández-Tardón, Guillermo
- dc.contributor.author Jiménez-Moleón, José Juan
- dc.contributor.author Alguacil Ojeda, Juan
- dc.contributor.author Chirlaque, María Dolores
- dc.contributor.author Toledo, Estefania
- dc.contributor.author Pérez-Gómez, Beatriz
- dc.contributor.author Pollan, Marina
- dc.contributor.author Kogevinas, Manolis
- dc.contributor.author Martín, Vicente
- dc.date.accessioned 2022-01-21T07:35:53Z
- dc.date.available 2022-01-21T07:35:53Z
- dc.date.issued 2020
- dc.description.abstract Several anticancer properties have been largely attributed to phenolics in in vivo and in vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not been studied in relation to gastric cancer (GC). The aim of this study was to assess the relationship between the intake of phenolic acids, stilbenes, and other phenolics and the risk of developing GC and its anatomical and histological subtypes. We used data from a multi-case-control study (MCC-Spain) obtained from different regions of Spain. We included 2700 controls and 329 GC cases. Odds ratios (ORs) were calculated using mixed effects logistic regression considering quartiles of phenolic intake. Our results showed an inverse association between stilbene and lignan intake and GC risk (ORQ4 vs. Q1 = 0.47; 95% CI: 0.32-0.69 and ORQ4 vs. Q1 = 0.53; 95% CI: 0.36-0.77, respectively). We found no overall association between total phenolic acid and other polyphenol class intake and GC risk. However, hydroxybenzaldehydes (ORQ4 vs. Q1 = 0.41; 95% CI: 0.28-0.61), hydroxycoumarins (ORQ4 vs. Q1 = 0.49; 95% CI: 0.34-0.71), and tyrosols (ORQ4 vs. Q1 = 0.56; 95% CI: 0.39-0.80) were inversely associated with GC risk. No differences were found in the analysis by anatomical or histological subtypes. In conclusion, a diet high in stilbenes, lignans, hydroxybenzaldehydes, hydroxycoumarins, and tyrosols was associated with a lower GC risk. Further prospective studies are needed to confirm our results.
- dc.format.mimetype application/pdf
- dc.identifier.citation Rubín-García M, Vitelli-Storelli F, Molina AJ, Zamora-Ros R, Aragonés N, Adarnaz E, et al. Association between polyphenol intake and gastric cancer risk by anatomic and histologic subtypes: MCC-Spain. Nutrients. 2020 Oct 26; 12(11): 3281. DOI: 10.3390/nu12113281
- dc.identifier.doi http://dx.doi.org/10.3390/nu12113281
- dc.identifier.issn 2072-6643
- dc.identifier.uri http://hdl.handle.net/10230/52275
- dc.language.iso eng
- dc.publisher MDPI
- dc.rights Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword MCC-Spain
- dc.subject.keyword Anatomic
- dc.subject.keyword Diet
- dc.subject.keyword Epidemiology
- dc.subject.keyword Gastric cancer
- dc.subject.keyword Histologic
- dc.subject.keyword Lignans
- dc.subject.keyword Phenolic acids
- dc.subject.keyword Polyphenols
- dc.subject.keyword Stilbenes
- dc.title Association between polyphenol intake and gastric cancer risk by anatomic and histologic subtypes: MCC-Spain
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion