Translation control: Learning from viruses, again

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• dc.contributor.author Díez Antón, Juana, 1962-ca
• dc.contributor.author Jungfleisch, Jennifer, 1986-ca
• dc.date.accessioned 2017-06-22T07:28:25Z
• dc.date.available 2017-06-22T07:28:25Z
• dc.date.issued 2017
• dc.description.abstract Viruses are powerful tools to uncover cellular processes. Through viral studies we have recently identified a novel translational control mechanism that involves the DEAD-box helicase Dhh1/DDX6 and RNA folding within coding sequences (CDSs). All Dhh1-dependent mRNAs, viral and cellular ones, (i) contain long and highly structured CDSs, (ii) are directly bound by Dhh1 with a specific pattern, (iii) are activated at the translation initiation step and (iv) express proteins associated with the endoplasmic reticulum. The obtained results uncover a novel layer of translation regulation associated with translation at the endoplasmic reticulum conserved from yeast to humans and hijacked by viruses.
• dc.description.sponsorship This work was supported by the Spanish Ministry of Economy and Competitiveness through grant BFU2016–80039-R (AEI/MINEICO/FEDER, UE) and the “Maria de Maeztu” Program for Units of Excellence in R&D (MDM-2014–0370).
• dc.format.mimetype application/pdfca
• dc.identifier.citation Díez Antón J, Jungfleisch J. Translation control: Learning from viruses, again. RNA Biology. 2017;14(7):835-7. DOI: 10.1080/15476286.2017.1325068
• dc.identifier.doi http://dx.doi.org/10.1080/15476286.2017.1325068
• dc.identifier.issn 1547-6286
• dc.identifier.uri http://hdl.handle.net/10230/32391
• dc.language.iso eng
• dc.publisher Taylor & Francis (Routledge)ca
• dc.relation.ispartof RNA Biology. 2017;14(7):835-7
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2016-80039-R
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/MDM2014-0370
• dc.rights © Taylor & Francis. This is an electronic version of an article published in Díez Antón J, Jungfleisch J. Translation control: Learning from viruses, again. RNA Biology. 2017 [Epub ahead of print]. RNA Biology is available online at: www.tandfonline.com http://dx.doi.org/10.1080/15476286.2017.1325068.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword BMV
• dc.subject.keyword Dhh1
• dc.subject.keyword Helicase
• dc.subject.keyword RNA secondary structure
• dc.subject.keyword Translational regulation
• dc.subject.keyword Viral RNA
• dc.title Translation control: Learning from viruses, againca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion