Trajectories of antidepressant use and 6-year change in body weight: a prospective population-based cohort study

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  • dc.contributor.author Lassale, Camille
  • dc.contributor.author Lugon, Gabriela
  • dc.contributor.author Hernáez, Álvaro
  • dc.contributor.author Frank, Philipp
  • dc.contributor.author Marrugat de la Iglesia, Jaume
  • dc.contributor.author Ramos, Rafel
  • dc.contributor.author Garre-Olmo, Josep
  • dc.contributor.author Elosua Llanos, Roberto
  • dc.date.accessioned 2025-02-26T07:14:11Z
  • dc.date.available 2025-02-26T07:14:11Z
  • dc.date.issued 2024
  • dc.description.abstract Background: Antidepressant drug treatment may be associated with weight gain, but long-term studies are lacking. Methods: We included 3,127 adults (1,701 women) from the REGICOR study, aged 55.6 (SD = 11.6) years on average in 2003-2006, living in the northeast of Spain. They had data at two time points (baseline and a median of 6.3 years later) on self-reported antidepressant use, body weight and height, and on baseline smoking, physical activity, diet quality, education, civil status, and depressive symptoms assessed with the Patient Health Questionnaire (PHQ-9) at follow-up. We defined four trajectories of antidepressant use as follows: never use, new use at follow-up, initial use discontinued, repeated use at both time points. We used multivariable linear models to estimate the association of these trajectories with the percentage of weight change. In people without obesity at baseline (n = 2,404), we also estimated the association with obesity incidence at follow-up. Results: The average 6-year weight gain was 0.53 kg (1.01% body weight), and 24.5% of the participants gained >5% of body weight. The majority (83.6%) of participants did not report any use of antidepressants, 6.2% initiated during follow-up, 5.1% discontinued it, and 5.1% reported their use at both time points. In multivariable analyses, compared to never users, all trajectories were associated with greater weight gain: +1.78% (0.57, 2.98) for initial use discontinued, +2.08% (0.97, 3.19) for new use at follow-up, and +1.98% (95% CI: 0.75, 3.20) for repeated use. In non-obese participants at baseline (n = 2,404), the odds ratio for becoming obese was 2.06 (1.03, 3.96) for repeated use and non-statistically significant for the other trajectories. Conclusions: In a population-based adult cohort, repeated use of antidepressants was strongly associated with weight gain. New and discontinued use was associated with weight gain, but non-significantly to obesity incidence. Given the global obesity epidemic and the widespread use of antidepressants, weight management and metabolic monitoring should be encouraged and integrated into depression follow-up guidelines alongside antidepressant prescriptions.
  • dc.description.sponsorship The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. The study was funded by the Carlos III Health Institute CIBERCV (CB16/11/00246). CL is supported by a Ramon y Cajal Fellowship RYC2020-029599 funded by MICIU/AEI/10.13039/501100011033 and the European Social Fund “Invest in your future”. She was supported by a fellowship from “La Caixa” Foundation (ID 100010434) and from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 847 648. The fellowship code is LCF/BQ/PR21/11840003. The REGICOR study was funded by the Carlos III Health Institute–European Regional Development Fund (FIS PI12/00232; FIS PI15/00051, CIBERCV, CIBERESP), and the Government of Catalonia through the Agency for Management of University and Research Grants (PERIS SLT002/16/00088, 2017SGR222). The funding bodies had no role in the study design, collection, analysis, and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Lassale C, Lugon G, Hernáez Á, Frank P, Marrugat J, Ramos R, et al. Trajectories of antidepressant use and 6-year change in body weight: a prospective population-based cohort study. Front Psychiatry. 2024 Dec 24;15:1464898. DOI: 10.3389/fpsyt.2024.1464898
  • dc.identifier.doi http://dx.doi.org/10.3389/fpsyt.2024.1464898
  • dc.identifier.issn 1664-0640
  • dc.identifier.uri http://hdl.handle.net/10230/69746
  • dc.language.iso eng
  • dc.publisher Frontiers
  • dc.relation.ispartof Front Psychiatry. 2024 Dec 24;15:1464898
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/847648
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RYC2020-029599
  • dc.rights © 2024 Lassale, Lugon, Hernáez, Frank, Marrugat, Ramos, Garre-Olmo and Elosua. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Anthropometrics
  • dc.subject.keyword Antidepressant
  • dc.subject.keyword Obesity
  • dc.subject.keyword Prospective study
  • dc.subject.keyword Weight change
  • dc.title Trajectories of antidepressant use and 6-year change in body weight: a prospective population-based cohort study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Articles (Departament de Medicina i Ciències de la Vida)
Articles (Hospital del Mar Research Institute)
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