Exposure to residential air pollution and the development of functional connectivity of brain networks throughout adolescence

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• dc.contributor.author Kusters, Michelle S.W.
• dc.contributor.author Granés, Laura
• dc.contributor.author Petricola, Sami
• dc.contributor.author Tiemeier, Henning
• dc.contributor.author Muetzel, Ryan L.
• dc.contributor.author Guxens Junyent, Mònica
• dc.date.accessioned 2025-02-26T07:12:30Z
• dc.date.available 2025-02-26T07:12:30Z
• dc.date.issued 2025
• dc.description.abstract Background: A few studies linked air pollution to differences in functional connectivity of resting-state brain networks in children, but how air pollution exposure affects the development of brain networks remains poorly understood. Therefore, we studied the association of air pollution exposure from birth to 3 years and one year before the first imaging assessment with the development of functional connectivity across adolescence. Methods: We utilized data from 3,626 children of the Generation R Study (The Netherlands). We estimated residential exposure to PM10, PM2.5, PM2.5 absorbance, NOX, and NO2 with land-use regression models. Between- and within-network functional connectivity was calculated for 13 cortical networks, and the amygdala, hippocampus, and caudate nucleus at two assessments (8.6-12.0 and 12.6-17.1 years), resulting in 4,628 scans (2,511 for assessment 1 and 2,117 for assessment 2) from 3,626 individuals. We investigated the association between air pollution and functional connectivity with linear mixed models adjusted for life-style and socioeconomic variables, and corrected for multiple testing. Results: Higher exposure to PM2.5 from birth to 3 years was associated with persistently lower functional connectivity over time between the amygdala and the ventral attention, somatomotor hand, and auditory networks throughout adolescence (e.g. -0.027 functional connectivity [95 % CI -0.040; -0.013] amygdala - ventral attention network per 5 μg/m3higher PM2.5). Higher exposure to PM10 one year before the first imaging assessment was associated with persistently lower functional connectivity between the salience and medial-parietal networks throughout adolescence. Air pollution was not associated with a faster or slower change in functional connectivity with age. Conclusions: Air pollution exposure early in life was associated with persistent alterations in connectivity between the amygdala and cortical networks involved in attention, somatomotor, and auditory function. Concurrent exposure was associated with persistent connectivity alterations between networks related to higher cognitive functions (i.e. the salience and medial-parietal networks).
• dc.description.sponsorship This publication was co-financed by the Agencia Estatal de Investigación (AEI) and the European Social Fund (FSE) “ EL FSE invierte en tu futuro” with reference number PRE2020-092005, according to the Resolution of the Presidency of the AEI, by which grants are awarded for pre-doctoral contracts for the training of doctors, call 2020 (awarded to M.S.W.K). Neuroimaging data collection and analysis were supported by the Sophia Foundation project S18-20 (awarded to R.L.M.), the Netherlands Organization for Scientific Research (NWO, 2012.042, exacte wetenschap, Surf/Snellius, awarded to R.L.M) and the Netherlands Organization for Health Research and Development (ZonMw) Vici project 016.VICI.170.200 (awarded to H.T.). H.T. and R.L.M. were supported by the The European Union’s HorizonEurope Research and Innovation Programme (FAMILY, grant agreement No 101057529). M.G. was funded by a Miguel Servet II fellowship (CPII18/00018) and L.G was funded by a Rio Hortega fellowship (CM22/00011), both awarded from the Spanish Institute of Health Carlos III. The general design of Generation R Study is made possible by financial support from the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam, ZonMw, The Netherlands Organization for Scientific Research (NWO), and the Ministry of Health, Welfare, and Sport. The geocodification of the addresses of the study participants and the air pollution estimations were done within the framework of a project funded by the Health Effects Institute (HEI) (Assistance Award No. R-82811201). We acknowledge support from the grant CEX2023-0001290-S funded by MCIN/AEI/ 10.13039/501100011033, support from the Generalitat de Catalunya through the CERCA Program, and from the Ministry of Research and Universities of the Government of Catalonia (2021 SGR 01564). Data for generating figures were provided [in part] by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University.
• dc.format.mimetype application/pdf
• dc.identifier.citation Kusters MSW, Granés L, Petricola S, Tiemeier H, Muetzel RL, Guxens M. Exposure to residential air pollution and the development of functional connectivity of brain networks throughout adolescence. Environ Int. 2025 Jan 6;196:109245. DOI: 10.1016/j.envint.2024.109245
• dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2024.109245
• dc.identifier.issn 0160-4120
• dc.identifier.uri http://hdl.handle.net/10230/69741
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environ Int. 2025 Jan 6;196:109245
• dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101057529
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PRE2020-092005
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/CEX2023-0001290-S
• dc.rights © 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Air pollutants
• dc.subject.keyword Brain development
• dc.subject.keyword Cohort studies
• dc.subject.keyword Environmental pollution
• dc.subject.keyword Functional connectivity
• dc.subject.keyword Resting-statefunctional MRI
• dc.title Exposure to residential air pollution and the development of functional connectivity of brain networks throughout adolescence
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion