Associations of alcohol consumption with left atrial morphology and function in a population at high cardiovascular risk

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• dc.contributor.author Alam, Aniqa B.
• dc.contributor.author Toledo-Atucha, Estefania
• dc.contributor.author Romaguera Bosch, Dora
• dc.contributor.author Alonso-Gómez, Ángel
• dc.contributor.author Martínez-González, Miguel Ángel, 1957-
• dc.contributor.author Tojal Sierra, Lucas
• dc.contributor.author Noris Mora, Marta
• dc.contributor.author Mas-Lladó, Caterina
• dc.contributor.author Li, Linzi
• dc.contributor.author González-Casanova, Inés
• dc.contributor.author Salas Salvadó, Jordi
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Alonso, Álvaro
• dc.date.accessioned 2025-07-01T06:09:28Z
• dc.date.available 2025-07-01T06:09:28Z
• dc.date.issued 2024
• dc.description.abstract Background: Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structural and functional left atrial measures, however, has received limited attention. Methods and results: We studied 503 participants from the PREDIMED-Plus (Prevención con Dieta Mediterránea) trial, a randomized trial testing intensive weight loss intervention with an energy-reduced Mediterranean diet and physical activity promotion in preventing cardiovascular disease in adults with metabolic syndrome. Participants underwent transthoracic echocardiography at baseline, year 3, and year 5 of the study. Outcomes of interest included volume index and reservoir, conduit, and contractile strains of the left atrium. Alcohol consumption was calculated through food frequency questionnaires and presented as drinks consumed per day. Multiple linear regression and mixed models estimated the association of alcohol consumption with left atrial measurements at baseline and through follow-up. Cross-sectionally, higher alcohol consumption (per 1 drink/day increases) was associated with larger left atrial volume (0.65 mL/m2 [95% CI, 0.18-1.11]) and lower left atrial reservoir and contractile strain (-0.44% [95% CI, -0.87 to -0.01]; and -0.44% [95% CI, -0.75 to -0.14]). Baseline alcohol consumption was not associated with changes in left atrial measurements, but increases in alcohol consumption (per 1 drink/day increase) during follow-up were associated with left atrial enlargement (0.71 mL/m2 [95% CI, 0.17-1.26]). Conclusions: In a population at high cardiovascular risk, increased alcohol consumption was associated with left atrial enlargement and worsening atrial function. Registration: URL: http://www.controlled-trials.com; Unique identifier: ISRCTN89898870.
• dc.description.sponsorship This study was supported by the National Institutes of Health/National Heart, Lung, and Brain Institute under award number R01HL137338 and K24HL148521. The PREDIMED‐Plus trial was supported by the European Research Council (Advanced Research Grant 2014–2014, number 340918 awarded to M.A.M.‐G. as principal investigator of the trial), and by the official funding agency for biomedical research of the Spanish Government, Instituto de Salud Carlos III ([Carlos III Health Institute], Sevilla, Spain), through the Fondo de Investigación para la Salud, which is cofunded by the European Regional Development Fund (PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/0147, PI14/00636, PI14/00972, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158), the Recercaixa grant (2013ACUP00194), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, PI0137/2018), the PROMETEO/2017/017 grant from the Generalitat Valenciana, the Sociedad Española de Médicos de Atención Primaria grant, and European Regional Development Fund funds CB06/03.
• dc.format.mimetype application/pdf
• dc.identifier.citation Alam AB, Toledo-Atucha E, Romaguera D, Alonso-Gómez AM, Martínez-Gonzalez MA, Tojal-Sierra L, et al. Associations of alcohol consumption with left atrial morphology and function in a population at high cardiovascular risk. J Am Heart Assoc. 2024 Apr 2;13(7):e031915. DOI: 10.1161/JAHA.123.031915
• dc.identifier.doi http://dx.doi.org/10.1161/JAHA.123.031915
• dc.identifier.issn 2047-9980
• dc.identifier.uri http://hdl.handle.net/10230/70804
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof J Am Heart Assoc. 2024 Apr 2;13(7):e031915
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/340918
• dc.rights © 2024 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Alcohol consumption
• dc.subject.keyword Atrial fibrillation
• dc.subject.keyword Atrial structure and function
• dc.title Associations of alcohol consumption with left atrial morphology and function in a population at high cardiovascular risk
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion