Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe

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• dc.contributor.author Uphoff, Eleonora P.ca
• dc.contributor.author Antó i Boqué, Josep Mariaca
• dc.contributor.author Sunyer Deu, Jordica
• dc.contributor.author Wright, Johnca
• dc.date.accessioned 2017-12-13T16:15:16Z
• dc.date.available 2017-12-13T16:15:16Z
• dc.date.issued 2017
• dc.description.abstract While there is evidence for variations in prevalence rates of childhood wheeze and asthma between countries, longitudinal, individual-level data are needed to understand these differences. The aim of this study was to examine variations in prevalence rates of childhood asthma, wheeze and wheeze with asthma in Europe. We analysed datasets from 10 MeDALL (Mechanisms of the Development of ALLergy) cohorts in eight countries, representing 26 663 children, to calculate prevalence rates of wheeze and asthma by child age and wheeze with asthma at age 4 years. Harmonised variables included outcomes parent-reported wheeze and parent-reported doctor-diagnosed asthma, and covariates maternal education, parental smoking, pets, parental asthma, doctor-diagnosed allergic rhinitis, doctor-diagnosed eczema and wheeze severity. At age 4 years, asthma prevalence varied from 1.72% in Germany to 13.48% in England and the prevalence of wheeze varied from 9.82% in Greece to 55.37% in Spain. Adjusted estimates of the proportion of 4-year-old children with wheeze diagnosed with asthma remained highest in England (38.14%, 95% CI 31.38–44.90%) and lowest in Spain (15.94%, 95% CI 6.16–25.71%). The large differences in prevalence rates of asthma, wheeze and wheeze with asthma at age 4 years between European cohorts may indicate that childhood asthma is more readily diagnosed in some countries while going unrecognised elsewhere.
• dc.description.sponsorship The MeDALL collaboration is funded by European Union Seventh Framework Programme grant agreement number 261357.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Uphoff EP, Bird PK, Antó JM, Basterrechea M, von Berg A, Bergström A et al. Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe. ERJ Open Res. 2017 Jul 3;3(3). pii: 00150-2016. DOI: 10.1183/23120541.00150-2016
• dc.identifier.doi http://dx.doi.org/10.1183/23120541.00150-2016
• dc.identifier.issn 2312-0541
• dc.identifier.uri http://hdl.handle.net/10230/33478
• dc.language.iso eng
• dc.publisher European Respiratory Societyca
• dc.relation.ispartof ERJ Open Res. 2017 Jul 3;3(3). pii: 00150-2016
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
• dc.rights © ERS 2017. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0 (https://creativecommons.org/licenses/by-nc/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Sleep medicine
• dc.subject.keyword COPD and smoking
• dc.subject.keyword Asthma and allergy
• dc.subject.keyword Childhood asthma
• dc.title Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europeca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion