SNP and haplotype mapping for genetic analysis in the rat
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- dc.contributor.author The STAR consortium
- dc.contributor.author Guigó Serra, Roderic
- dc.contributor.author López Bigas, Núria
- dc.contributor.author Shikhagaie, Medya
- dc.contributor.author Hubner, Norbert
- dc.date.accessioned 2019-03-27T08:43:42Z
- dc.date.available 2019-03-27T08:43:42Z
- dc.date.issued 2008
- dc.description.abstract The laboratory rat is one of the most extensively studied model organisms. Inbred laboratory rat strains originated from limited Rattus norvegicus founder populations, and the inherited genetic variation provides an excellent resource for the correlation of genotype to phenotype. Here, we report a survey of genetic variation based on almost 3 million newly identified SNPs. We obtained accurate and complete genotypes for a subset of 20,238 SNPs across 167 distinct inbred rat strains, two rat recombinant inbred panels and an F2 intercross. Using 81% of these SNPs, we constructed high-density genetic maps, creating a large dataset of fully characterized SNPs for disease gene mapping. Our data characterize the population structure and illustrate the degree of linkage disequilibrium. We provide a detailed SNP map and demonstrate its utility for mapping of quantitative trait loci. This community resource is openly available and augments the genetic tools for this workhorse of physiological studies.
- dc.description.sponsorship This work was supported by European Union grants LSGH-2004-005235 and LSHG-CT-2005-019015. D.G. is supported by a Wellcome Trust Senior Fellowship in Basic Biomedical Science (057733/Z/99/A). M.-T.B. and D.G. acknowledge support from the Wellcome Cardiovascular Functional Genomics Initiative (066780/Z/01/Z)
- dc.format.mimetype application/pdf
- dc.identifier.citation STAR Consortium, Saar K, Beck A, Bihoreau MT, Birney E, Brocklebank D et al. SNP and haplotype mapping for genetic analysis in the rat. Nat Genet. 2008 May;40(5):560-6. DOI: 10.1038/ng.124
- dc.identifier.doi http://dx.doi.org/10.1038/ng.124
- dc.identifier.issn 1061-4036
- dc.identifier.uri http://hdl.handle.net/10230/36972
- dc.language.iso eng
- dc.publisher Nature Research
- dc.relation.ispartof Nature Genetics. 2008 May;40(5):560-6
- dc.rights © Nature Publishing Group
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.other Genètica -- Bases de dades
- dc.subject.other Haplotip
- dc.subject.other Polimorfisme de nucleòtids simples
- dc.subject.other Locus de caràcters quantitatius
- dc.subject.other Rates -- Genètica
- dc.title SNP and haplotype mapping for genetic analysis in the rat
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion