Antidepressant drugs and COVID-19: A review of basic and clinical evidence
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- dc.contributor.author Mas, Marta
- dc.contributor.author García-Vicente, Juan Antonio
- dc.contributor.author Estrada-Gelonch, Anaïs
- dc.contributor.author Pérez Mañá, Clara
- dc.contributor.author Papaseit Fontanet, Esther
- dc.contributor.author Torrens, Marta
- dc.contributor.author Farré Albaladejo, Magí
- dc.date.accessioned 2023-02-02T13:29:58Z
- dc.date.available 2023-02-02T13:29:58Z
- dc.date.issued 2022
- dc.description.abstract The COVID-19 pandemic has encouraged the repurposing of existing drugs as a shorter development strategy in order to support clinicians with this difficult therapeutic dilemma. There is evidence to support the theory that some antidepressants can reduce concentrations of different cytokines in humans and animals and, recently, the antiviral activity of some antidepressants against SARS-CoV-2 has been reported. The aims of this narrative review are to evaluate the possible role of antidepressants in the treatment of COVID-19 infection and the possible benefits and risks of patients taking antidepressants for mental disorders and COVID-19 infection. A review was performed to analyse the current literature to identify the role of antidepressant medication in the treatment of COVID-19 patients. The electronic search was completed in MEDLINE and MedRxiv/BioRxiv for published literature and in ClinicalTrials.gov for ongoing clinical trials. The results show some evidence from preclinical data and observational studies about the possible efficacy of some specific antidepressants for treating COVID-19 infection. In addition, two published phase II studies testing fluvoxamine showed positive results for clinical deterioration and hospitalization rate versus a placebo. Seven ongoing clinical trials testing fluvoxamine, fluoxetine, and tramadol (as per its anti-inflammatory and antidepressant effect) are still in the early phases. Although the available evidence is limited, the sum of the antiviral and anti-inflammatory preclinical studies and the results from several observational studies and two phase II clinical trials provide the basis for ongoing clinical trials evaluating the possible use of antidepressants for COVID-19 infection in humans. Further investigations will be needed to support the possible use of antidepressants for this application.
- dc.format.mimetype application/pdf
- dc.identifier.citation Mas M, García-Vicente JA, Estrada-Gelonch A, Pérez-Mañá C, Papaseit E, Torrens M, Farré M. Antidepressant drugs and COVID-19: A review of basic and clinical evidence. J Clin Med. 2022 Jul 12;11(14):4038. DOI: 10.3390/jcm11144038
- dc.identifier.doi http://dx.doi.org/10.3390/jcm11144038
- dc.identifier.issn 2077-0383
- dc.identifier.uri http://hdl.handle.net/10230/55595
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof J Clin Med. 2022 Jul 12;11(14):4038
- dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword COVID-19
- dc.subject.keyword SARS-CoV-2
- dc.subject.keyword Antidepressant
- dc.subject.keyword Antiviral
- dc.subject.keyword Cytokine storm
- dc.subject.keyword Fluoxetine
- dc.subject.keyword Fluvoxamine
- dc.title Antidepressant drugs and COVID-19: A review of basic and clinical evidence
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion