Comprehensive multimorbidity patterns in older patients are associated with quality indicators of medication-MoPIM cohort study
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- dc.contributor.author Lleal, Marina
- dc.contributor.author Baré, Marisa
- dc.contributor.author Ortonobes, Sara
- dc.contributor.author Sevilla-Sánchez, Daniel
- dc.contributor.author Jordana, Rosa
- dc.contributor.author Herranz, Susana
- dc.contributor.author Queralt Gorgas, Maria
- dc.contributor.author Espaulella-Ferrer, Mariona
- dc.contributor.author Arellano Pérez, Marta
- dc.contributor.author Antonio, Marta de
- dc.contributor.author Nazco, Gloria Julia
- dc.contributor.author Hernández-Luis, Rubén
- dc.contributor.author MoPIM study group
- dc.date.accessioned 2023-04-11T06:37:39Z
- dc.date.available 2023-04-11T06:37:39Z
- dc.date.issued 2022
- dc.description.abstract Multimorbidity is increasing and poses a challenge to the clinical management of patients with multiple conditions and drug prescriptions. The objectives of this work are to evaluate if multimorbidity patterns are associated with quality indicators of medication: potentially inappropriate prescribing (PIP) or adverse drug reactions (ADRs). A multicentre prospective cohort study was conducted including 740 older (≥65 years) patients hospitalised due to chronic pathology exacerbation. Sociodemographic, clinical and medication related variables (polypharmacy, PIP according to STOPP/START criteria, ADRs) were collected. Bivariate analyses were performed comparing previously identified multimorbidity clusters (osteoarticular, psychogeriatric, minor chronic disease, cardiorespiratory) to presence, number or specific types of PIP or ADRs. Significant associations were found in all clusters. The osteoarticular cluster presented the highest prevalence of PIP (94.9%) and ADRs (48.2%), mostly related to anxiolytics and antihypertensives, followed by the minor chronic disease cluster, associated with ADRs caused by antihypertensives and insulin. The psychogeriatric cluster presented PIP and ADRs of neuroleptics and the cardiorespiratory cluster indicators were better overall. In conclusion, the associations that were found reinforce the existence of multimorbidity patterns and support specific medication review actions according to each patient profile. Thus, determining the relationship between multimorbidity profiles and quality indicators of medication could help optimise healthcare processes. Trial registration number: NCT02830425.
- dc.format.mimetype application/pdf
- dc.identifier.citation Lleal M, Baré M, Ortonobes S, Sevilla-Sánchez D, Jordana R, Herranz S, Gorgas MQ, Espaulella-Ferrer M, Arellano M, de Antonio M, Nazco GJ, Hernández-Luis R, On Behalf Of The MoPIM Study Group. Comprehensive multimorbidity patterns in older patients are associated with quality indicators of medication-MoPIM cohort study. Int J Environ Res Public Health. 2022 Nov 29;19(23):15902. DOI: 10.3390/ijerph192315902
- dc.identifier.doi http://dx.doi.org/10.3390/ijerph192315902
- dc.identifier.issn 1661-7827
- dc.identifier.uri http://hdl.handle.net/10230/56432
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Int J Environ Res Public Health. 2022 Nov 29;19(23):15902
- dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Adverse drug reaction
- dc.subject.keyword Cluster analysis
- dc.subject.keyword Healthcare quality indicator
- dc.subject.keyword Multimorbidity
- dc.subject.keyword Older patient
- dc.subject.keyword Polypharmacy
- dc.subject.keyword Potential prescribing omission
- dc.subject.keyword Potentially inappropriate medication
- dc.title Comprehensive multimorbidity patterns in older patients are associated with quality indicators of medication-MoPIM cohort study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion