CAPS-DB: A structural classification of helix-capping motifs
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- dc.contributor.author Segura, Joanca
- dc.contributor.author Oliva Miguel, Baldomeroca
- dc.contributor.author Fernández Fuentes, Narcísca
- dc.date.accessioned 2015-04-07T09:36:23Z
- dc.date.available 2015-04-07T09:36:23Z
- dc.date.issued 2012ca
- dc.description.abstract The regions of the polypeptide chain immediately preceding or following an α-helix are known as Nt- and Ct cappings, respectively. Cappings play a central role stabilizing α-helices due to lack of intrahelical hydrogen bonds in the first and last turn. Sequence patterns of amino acid type preferences have been derived for cappings but the structural motifs associated to them are still unclassified. CAPS-DB is a database of clusters of structural patterns of different capping types. The clustering algorithm is based in the geometry and the (ϕ–ψ)-space conformation of these regions. CAPS-DB is a relational database that allows the user to search, browse, inspect and retrieve structural data associated to cappings. The contents of CAPS-DB might be of interest to a wide range of scientist covering different areas such as protein design and engineering, structural biology and bioinformatics. The database is accessible at: http://www.bioinsilico.org/CAPSDB.en
- dc.description.sponsorship Research Councils United Kingdom Academic Fellow scheme (to N.F.F.); internal scholarship awarded by the Leeds Institute of Molecular Medicine (to J.S.M.); MICINN and FEDER (BIO2011-22568) to B.O. Funding for open access charge: Research Councils United Kingdom (RCUK)en
- dc.format.mimetype application/pdfca
- dc.identifier.citation Segura J, Oliva B, Fernandez-Fuentes N. CAPS-DB: A structural classification of helix-capping motifs. Nucleic Acids Research. 2012;40(D1):D479-D485. DO:I 10.1093/nar/gkr879ca
- dc.identifier.doi http://dx.doi.org/10.1093/nar/gkr879
- dc.identifier.issn 0305-1048ca
- dc.identifier.uri http://hdl.handle.net/10230/23345
- dc.language.iso engca
- dc.publisher Oxford University Pressca
- dc.relation.ispartof Nucleic Acids Research. 2012;40(D1):D479-D485
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2011-22568
- dc.rights © Segura J, Oliva B, Fernandez-Fuentes N [2012]. Published by Oxford University Press. This is an Open Access article distributed under the terms of a Creative Commons Attribution Licenseca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0
- dc.subject.other Aminoàcidsca
- dc.subject.other Pèptidsca
- dc.subject.other Proteïnes -- Estructuraca
- dc.title CAPS-DB: A structural classification of helix-capping motifsen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca