Firefighters and the liver: Exposure to PFAS and PAHs in relation to liver function and serum lipids (CELSPAC-FIREexpo study)

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• dc.contributor.author Pálešová, Nina
• dc.contributor.author Maitre, Léa
• dc.contributor.author Stratakis, Nikos
• dc.contributor.author Řiháčková, Katarína
• dc.contributor.author Pindur, Aleš
• dc.contributor.author Kohoutek, Jir̂í
• dc.contributor.author Šenk, Petr
• dc.contributor.author Bartošková Polcrová, Anna
• dc.contributor.author Gregor, Petr
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Čupr, Pavel
• dc.date.accessioned 2023-11-22T07:52:01Z
• dc.date.available 2023-11-22T07:52:01Z
• dc.date.issued 2023
• dc.description.abstract Introduction: Firefighting is one of the most hazardous occupations due to exposure to per- and polyfluoroalkyl substances (PFAS) and polycyclic aromatic hydrocarbons (PAHs). Such exposure is suspected to affect the cardiometabolic profile, e.g., liver function and serum lipids. However, only a few studies have investigated the impact of this specific exposure among firefighters. Methods: Men included in the CELSPAC-FIREexpo study were professional firefighters (n = 52), newly recruited firefighters in training (n = 58), and controls (n = 54). They completed exposure questionnaires and provided 1-3 samples of urine and blood during the 11-week study period to allow assessment of their exposure to PFAS (6 compounds) and PAHs (6 compounds), and to determine biomarkers of liver function (alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and total bilirubin (BIL)) and levels of serum lipids (total cholesterol (CHOL), low-density lipoprotein cholesterol (LDL) and triglycerides (TG)). The associations between biomarkers were investigated both cross-sectionally using multiple linear regression (MLR) and Bayesian weighted quantile sum (BWQS) regression and prospectively using MLR. The models were adjusted for potential confounders and false discovery rate correction was applied to account for multiplicity. Results: A positive association between exposure to PFAS and PAH mixture and BIL (β = 28.6%, 95% CrI = 14.6-45.7%) was observed by the BWQS model. When the study population was stratified, in professional firefighters and controls the mixture showed a positive association with CHOL (β = 29.5%, CrI = 10.3-53.6%) and LDL (β = 26.7%, CrI = 8.3-48.5%). No statistically significant associations with individual compounds were detected using MLR. Conclusions: This study investigated the associations between exposure to PFAS and PAHs and biomarkers of cardiometabolic health in the Czech men, including firefighters. The results suggest that higher exposure to a mixture of these compounds is associated with an increase in BIL and the alteration of serum lipids, which can result in an unfavourable cardiometabolic profile.
• dc.description.sponsorship This work was funded by the European Union's Horizon 2020 research and innovation program under grant agreement No 857487 and supported under grant agreement No 857340, grant agreement No 857560 and grant agreement No 874627. This work was supported by the project National Institute for Research of Metabolic and Cardiovascular Diseases (Programme EXCELES, ID Project No. LX22NPO5104) - Funded by the European Union – Next Generation EU. This work was supported by the European Union's Horizon Europe research and innovation programme in the framework of the European Partnership for the Assessment of Risks from Chemicals (PARC) under grant agreement No 101057014. Views and opinions expressed are however those of the authors only and do not necessarily reflect those of the European Union or the Health and Digital Executive Agency. Neither the European Union nor the granting authority can be held responsible for them.
• dc.format.mimetype application/pdf
• dc.identifier.citation Pálešová N, Maitre L, Stratakis N, Řiháčková K, Pindur A, Kohoutek J, Šenk P, Bartošková Polcrová A, Gregor P, Vrijheid M, Čupr P. Firefighters and the liver: Exposure to PFAS and PAHs in relation to liver function and serum lipids (CELSPAC-FIREexpo study). Int J Hyg Environ Health. 2023 Jul;252:114215. DOI: 10.1016/j.ijheh.2023.114215
• dc.identifier.doi http://dx.doi.org/10.1016/j.ijheh.2023.114215
• dc.identifier.issn 1438-4639
• dc.identifier.uri http://hdl.handle.net/10230/58354
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Int J Hyg Environ Health. 2023 Jul;252:114215
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/857487
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/857340
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/857560
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874627
• dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101057014
• dc.rights © 2023 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Firefighters
• dc.subject.keyword Liver function
• dc.subject.keyword Mixture analysis
• dc.subject.keyword Occupational exposure
• dc.subject.keyword Polycyclic aromatic hydrocarbons/PAHs
• dc.subject.keyword per- and polyfluoroalkyl substances/PFAS
• dc.title Firefighters and the liver: Exposure to PFAS and PAHs in relation to liver function and serum lipids (CELSPAC-FIREexpo study)
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion