Synthetic cannabinoids use in a sample of opioid-use disorder patients

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• dc.contributor.author Alías Ferri, María
• dc.contributor.author Pellegrini, Manuela
• dc.contributor.author Marchei, Emilia
• dc.contributor.author Pacifici, Roberta
• dc.contributor.author Rotolo, Maria Concetta
• dc.contributor.author Pichini, Simona
• dc.contributor.author Pérez Mañá, Clara
• dc.contributor.author Papaseit Fontanet, Esther
• dc.contributor.author Muga, Roberto
• dc.contributor.author Fonseca Casals, Francina, 1972-
• dc.contributor.author Farré Albaladejo, Magí
• dc.contributor.author Torrens, Marta
• dc.date.accessioned 2023-02-15T07:29:08Z
• dc.date.available 2023-02-15T07:29:08Z
• dc.date.issued 2022
• dc.description.abstract Cannabis is the most widely consumed illegal drug in the world and synthetic cannabinoids are increasingly gaining popularity and replacing traditional cannabis. These substances are a type of new psychoactive substance that mimics the cannabis effects but often are more severe. Since, people with opioids use disorder use widely cannabis, they are a population vulnerable to use synthetic cannabinoids. In addition, these substances are not detected by the standard test used in the clinical practice and drug-checking is more common in recreational settings. A cross-sectional study with samples of 301 opioid use disorder individuals was carried out at the addiction care services from Barcelona and Badalona. Urinalysis was performed by high-sensitivity gas chromatography-mass spectrometry (GC-MS) and ultra-high-performance liquid chromatography-high -resolution mass spectrometry (UHPLC-HRMS). Any synthetic cannabinoid was detected in 4.3% of the individuals and in 23% of these samples two or more synthetic cannabinoids were detected. Among the 8 different synthetic cannabinoids detected, most common were JWH-032 and JWH-122. Natural cannabis was detected in the 18.6% of the samples and only in the 0.7% of them THC was identified. Several different synthetic cannabinoids were detected and a non-negligible percentage of natural cannabis was detected among our sample. Our results suggest that the use of synthetic cannabinoids may be related to the avoidance of detection. In the absence of methods for the detection of these substances in clinical practice, there are insufficient data and knowledge making difficult to understand about this phenomenon among opioid use disorder population.
• dc.format.mimetype application/pdf
• dc.identifier.citation Alías-Ferri M, Pellegrini M, Marchei E, Pacifici R, Rotolo MC, Pichini S, et al. Synthetic cannabinoids use in a sample of opioid-use disorder patients. Front Psychiatry. 2022 Aug 3; 13: 956120. DOI: 10.3389/fpsyt.2022.956120
• dc.identifier.doi http://dx.doi.org/10.3389/fpsyt.2022.956120
• dc.identifier.issn 1664-0640
• dc.identifier.uri http://hdl.handle.net/10230/55777
• dc.language.iso eng
• dc.publisher Frontiers
• dc.rights Copyright © 2022 Alías-Ferri, Pellegrini, Marchei, Pacifici, Rotolo, Pichini, Pérez-Mañá, Papaseit, Muga, Fonseca, Farré and Torrens. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). http://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cannabis
• dc.subject.keyword New psychoactive substances
• dc.subject.keyword Opioid use disorder
• dc.subject.keyword Synthetic cannabinoid
• dc.subject.keyword Urine sample analysis
• dc.title Synthetic cannabinoids use in a sample of opioid-use disorder patients
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion