Stability studies of antipseudomonal beta lactam agents for outpatient therapy

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• dc.contributor.author Fernández Rubio, Beatriz
• dc.contributor.author Herrera Hidalgo, Laura
• dc.contributor.author Alarcón, Arístides de
• dc.contributor.author Luque Márquez, Rafael
• dc.contributor.author López-Cortés, Luis E.
• dc.contributor.author Luque Pardos, Sònia
• dc.contributor.author Gutiérrez Urbón, José María
• dc.contributor.author Fernández Polo, Aurora
• dc.contributor.author Gutiérrez Valencia, Alicia
• dc.contributor.author Gil Navarro, María V.
• dc.date.accessioned 2024-11-04T06:49:29Z
• dc.date.available 2024-11-04T06:49:29Z
• dc.date.issued 2023
• dc.description.abstract Outpatient parenteral antimicrobial therapy (OPAT) is a useful treatment strategy against Pseudomonas aeruginosa and other multidrug-resistant bacteria. However, it is hindered by the lack of stability data for the administration of antibiotics under OPAT conditions. Our objective was to investigate the stability of nine antipseudomonal and broad-spectrum beta lactam antibiotics (aztreonam, cefepime, cefiderocol, ceftazidime, ceftazidime/avibactam, ceftolozane/tazobactam, meropenem, meropenem/vaborbactam, and piperacillin/tazobactam) to allow the spread of OPAT programs. All the antibiotics were diluted in 500 mL 0.9% sodium chloride and stored at 4, 25, 32, and 37 °C for 72 h in two different devices (infusion bags and elastomeric pumps). The solutions were considered stable if the color, clearness, and pH remained unchanged and if the percentage of intact drug was ≥90%. All the antimicrobials remained stable 72 h under refrigerated conditions and at least 30 h at 25 °C. At 32 °C, all the antibiotics except for meropenem and meropenem/vaborbactam remained stable for 24 h or more. At 37 °C, only aztreonam, piperacillin/tazobactam, cefepime, cefiderocol, and ceftolozane/tazobactam were stable for at least 24 h. The stability results were the same in the two devices tested. All the antibiotics studied are actual alternatives for the treatment of antipseudomonal or multidrug-resistant infections in OPAT programs, although the temperature of the devices is crucial to ensure antibiotic stability.
• dc.format.mimetype application/pdf
• dc.identifier.citation Fernández-Rubio B, Herrera-Hidalgo L, Alarcón A, Luque-Márquez R, López-Cortés LE, Luque S, et al. Stability studies of antipseudomonal beta lactam agents for outpatient therapy. Pharmaceutics. 2023 Nov 30;15(12):2705. DOI: 10.3390/pharmaceutics15122705
• dc.identifier.doi http://dx.doi.org/10.3390/pharmaceutics15122705
• dc.identifier.issn 1999-4923
• dc.identifier.uri http://hdl.handle.net/10230/68408
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Pharmaceutics. 2023 Nov 30;15(12):2705
• dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Pseudomonas aeruginosa
• dc.subject.keyword Beta lactams
• dc.subject.keyword Multidrug-resistant bacteria
• dc.subject.keyword Outpatient parenteral antimicrobial therapy
• dc.subject.keyword Stability
• dc.title Stability studies of antipseudomonal beta lactam agents for outpatient therapy
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion