Signaling and Transcription Factors during Inner Ear Development: The Generation of Hair Cells and Otic Neurons

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• dc.contributor.author Gálvez García, Héctor, 1989-ca
• dc.contributor.author Abelló Sumpsi, Gina, 1980-ca
• dc.contributor.author Giráldez, Fernandoca
• dc.date.accessioned 2017-06-27T07:48:25Z
• dc.date.available 2017-06-27T07:48:25Z
• dc.date.issued 2017
• dc.description.abstract Integration between cell signals and bHLH transcription factors plays a prominent role during the development of hair cells of the inner ear. Hair cells are the sensory receptors of the inner ear, responsible for the mechano-transduction of sound waves into electrical signals. They derive from multipotent progenitors that reside in the otic placode. Progenitor commitment is the result of cell signaling from the surrounding tissues that result in the restricted expression of SoxB1 transcription factors, Sox2 and Sox3. In turn, they induce the expression of Neurog1 and Atoh1, two bHLH factors that specify neuronal and hair cell fates, respectively. Neuronal and hair cell development, however, do not occur simultaneously. Hair cell development is prevented during neurogenesis and prosensory stages, resulting in the delay of hair cell development with respect to neuron production. Negative interactions between Neurog1 and Atoh1, and of Atoh1 with other bHLH factors driven by Notch signaling, like Hey1 and Hes5, account for this delay. In summary, the regulation of Atoh1 and hair cell development relies on interactions between cell signaling and bHLH transcription factors that dictate cell fate and timing decisions during development. Interestingly, these mechanisms operate as well during hair cell regeneration after damage and during stem cell directed differentiation, making developmental studies instrumental for improving therapies for hearing impairment.
• dc.description.sponsorship We acknowledge support of La Marató and BFU2015-67400-P (MINECO/FEDER, UE).
• dc.format.mimetype application/pdfca
• dc.identifier.citation Gálvez H, Abelló Sumpsi G, Giráldez F. Signaling and Transcription Factors during Inner Ear Development: The Generation of Hair Cells and Otic Neurons. Frontiers in Cell and Developmental Biology. 2017;5:21. DOI: 10.3389/fcell.2017.00021
• dc.identifier.doi http://dx.doi.org/10.3389/fcell.2017.00021
• dc.identifier.issn 2296-634X
• dc.identifier.uri http://hdl.handle.net/10230/32468
• dc.language.iso eng
• dc.publisher Frontiersca
• dc.relation.ispartof Frontiers in Cell and Developmental Biology. 2017;5:21
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-67400-P
• dc.rights © 2017 Gálvez, Abelló and Giraldez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Atoh1
• dc.subject.keyword Neurog1
• dc.subject.keyword Hes and Hey factors
• dc.subject.keyword Notch signaling pathway
• dc.subject.keyword Cell fate specification
• dc.subject.keyword Hair cell regeneration
• dc.title Signaling and Transcription Factors during Inner Ear Development: The Generation of Hair Cells and Otic Neuronsca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion