Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author García-Escobar, Eva
• dc.contributor.author Goday Arno, Alberto
• dc.contributor.author Franch-Nadal, Josep
• dc.date.accessioned 2022-07-11T06:50:24Z
• dc.date.available 2022-07-11T06:50:24Z
• dc.date.issued 2021
• dc.description.abstract Our aim was to evaluate whether fatty liver index (FLI) is associated with the risk of type 2 diabetes (T2DM) development within the Spanish adult population and according to their prediabetes status; additionally, to examine its incremental predictive value regarding traditional risk factors. A total of 2260 subjects (Prediabetes: 641 subjects, normoglycemia: 1619 subjects) from the Di@bet.es cohort study were studied. Socio-demographic, anthropometric, clinical data and survey on habits were recorded. An oral glucose tolerance test was performed and fasting determinations of glucose, lipids and insulin were made. FLI was calculated and classified into three categories: Low (< 30), intermediate (30-60) and high (> 60). In total, 143 people developed diabetes at follow-up. The presence of a high FLI category was in all cases a significant independent risk factor for the development of diabetes. The inclusion of FLI categories in prediction models based on different conventional T2DM risk factors significantly increase the prediction power of the models when all the population was considered. According to our results, FLI might be considered an early indicator of T2DM development even under normoglycemic condition. The data also suggest that FLI could provide additional information for the prediction of T2DM in models based on conventional risk factors.
• dc.format.mimetype application/pdf
• dc.identifier.citation García-Escobar E, Valdés S, Soriguer F, Vendrell J, Urrutia-Etxebarria IM, Maldonado-Araque C, et al. Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study. Sci Rep. 2021 Aug 12; 11(1): 16453. DOI: 10.1038/s41598-021-95546-x
• dc.identifier.doi http://dx.doi.org/10.1038/s41598-021-95546-x
• dc.identifier.issn 2045-2322
• dc.identifier.uri http://hdl.handle.net/10230/53703
• dc.language.iso eng
• dc.publisher Nature Research
• dc.rights Copyright © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Fetge--Malalties
• dc.subject.keyword Diabetis no-insulinodependent
• dc.subject.keyword Glucèmia
• dc.title Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion