Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney
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- dc.contributor.author Wain, Louise V.ca
- dc.contributor.author Marrugat de la Iglesia, Jaumeca
- dc.contributor.author Elosua Llanos, Robertoca
- dc.contributor.author Ehret, Georg B.ca
- dc.date.accessioned 2018-06-05T07:18:38Z
- dc.date.issued 2017
- dc.description.abstract Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.
- dc.format.mimetype application/pdf
- dc.identifier.citation Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM. et al. Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension. 2017;70(3):e4-19. DOI: 10.1161/HYPERTENSIONAHA.117.09438
- dc.identifier.doi http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09438
- dc.identifier.issn 0194-911X
- dc.identifier.uri http://hdl.handle.net/10230/34820
- dc.language.iso eng
- dc.publisher American Hearth Associationca
- dc.relation.ispartof Hypertension. 2017;70(3):e4-19
- dc.rights © American Hearth Association http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09438
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword GWAS
- dc.subject.keyword Blood pressure
- dc.subject.keyword Cardiovascular risk
- dc.subject.keyword Complex traits
- dc.subject.keyword eSNP
- dc.subject.keyword Hypertension
- dc.subject.other Hipertensió
- dc.subject.other Sistema cardiovascular -- Malalties
- dc.title Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidneyca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion