Development of the adaptive NK cell response to human cytomegalovirus in the context of aging
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- dc.contributor.author López-Botet, M. (Miguel)ca
- dc.contributor.author Muntasell i Castellví, Aura, 1972-ca
- dc.contributor.author Martínez-Rodriguez, José E.ca
- dc.contributor.author López-Montañés, Maríaca
- dc.contributor.author Costa-García, Marcelca
- dc.contributor.author Pupuleku, Aldi, 1985-ca
- dc.date.accessioned 2017-01-11T09:51:01Z
- dc.date.issued 2016
- dc.description.abstract Human cytomegalovirus (HCMV) establishes a highly prevalent life-long latent infection. Though generally subclinical, HCMV infection may have severe consequences during fetal development and in immunocompromised individuals. Based on epidemiological studies HCMV(+) serology has been associated with the development of atherosclerosis, immune senescence and an increase mortality rate in elderly people. Such long-term detrimental effects of the viral infection presumably result from an inefficient immune control of the pathogen, depending on the quality and evolution of the individual host-pathogen relationship. Together with antigen-specific T lymphocytes, NK cells play an important role in anti-viral immune defense. HCMV promotes in some individuals the differentiation and persistent steady state expansion of an NK cell subset bearing the CD94/NKG2C activating receptor. The relationship between this adaptive NK cell response to HCMV and aging is overviewed.ca
- dc.description.sponsorship The team is supported by grants from Plan Estatal I + D Retos (SAF2013-49063-C2-1-R, MINECO-FEDER), Fundació La Marató de TV3 (121531) and REEM (RD12/0032/0016, Instituto de Salud Carlos III). AM is supported by Asociación Espanola ˜ Contra el Cáncer (AECC).
- dc.format.mimetype application/pdfca
- dc.identifier.citation López-Botet M, Muntasell A, Martínez-Rodríguez JE, López-Montañés M, Costa-García M, Pupuleku A. Development of the adaptive NK cell response to human cytomegalovirus in the context of aging. Mech Ageing Dev. 2016 Sep;158:23-6. DOI: 10.1016/j.mad.2016.06.010ca
- dc.identifier.doi http://dx.doi.org/10.1016/j.mad.2016.06.010
- dc.identifier.issn 0047-6374
- dc.identifier.uri http://hdl.handle.net/10230/27869
- dc.language.iso engca
- dc.publisher Elsevierca
- dc.relation.ispartof Mechanisms of Ageing and Development. 2016 Sep;158:23-6
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.mad.2016.06.010ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Envelliment -- Aspectes immunològicsca
- dc.subject.other Citomegalovirusca
- dc.title Development of the adaptive NK cell response to human cytomegalovirus in the context of agingca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca