Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase-control study (MCC-Spain)
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- dc.contributor.author Palomar Cros, Anna
- dc.contributor.author Straif, Kurt
- dc.contributor.author Romaguera Bosch, Dora
- dc.contributor.author Castaño Vinyals, Gemma
- dc.contributor.author Espinosa Díaz, Ana
- dc.contributor.author Kogevinas, Manolis
- dc.contributor.author Lassale, Camille
- dc.date.accessioned 2023-07-21T06:43:27Z
- dc.date.available 2023-07-21T06:43:27Z
- dc.date.issued 2023
- dc.description.abstract Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase-Control (MCC-Spain) study were recruited (2008-2013). The consumption of AS, from table-top sweeteners and artificially sweetened beverages, was assessed through a self-administered and validated food frequency questionnaire (FFQ). Sex-specific quartiles among controls were determined to compare moderate consumers (<third quartile) and high consumers (≥ third quartile) vs non consumers (reference category), distinguishing aspartame-containing products and other AS. Unconditional logistic regression models were used to estimate adjusted OR and 95%CI, and results were stratified by diabetes status. Overall, we found no associations between the consumption of aspartame or other AS and cancer. Among participants with diabetes, high consumption of other AS was associated with colorectal cancer (OR = 1.58, 95% CI 1.05-2.41, P trend = .03) and stomach cancer (OR = 2.27 [0.99-5.44], P trend = .06). High consumption of aspartame, was associated with stomach cancer (OR = 2.04 [0.7-5.4], P trend = .05), while a lower risk was observed for breast cancer (OR = 0.28 [0.08-0.83], P trend = .03). In some cancers, the number of cases in participants with diabetes were small and results should be interpreted cautiously. We did not find associations between use of AS and cancer, but found associations between high consumption of aspartame and other AS and different cancer types among participants with diabetes.
- dc.format.mimetype application/pdf
- dc.identifier.citation Palomar-Cros A, Straif K, Romaguera D, Aragonés N, Castaño-Vinyals G, Martin V, et al. Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase-control study (MCC-Spain). Int J Cancer. 2023 Sep 1;153(5):979-93. DOI: 10.1002/ijc.34577
- dc.identifier.doi http://dx.doi.org/10.1002/ijc.34577
- dc.identifier.issn 0020-7136
- dc.identifier.uri http://hdl.handle.net/10230/57635
- dc.language.iso eng
- dc.publisher Wiley
- dc.relation.ispartof Int J Cancer. 2023 Sep 1;153(5):979-93
- dc.rights © 2023 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
- dc.subject.keyword Artificial sweeteners
- dc.subject.keyword Aspartame
- dc.subject.keyword Cancer risk
- dc.subject.keyword Case-control
- dc.title Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase-control study (MCC-Spain)
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion