Quantification and progress over time of specific antibodies against severe acute respiratory syndrome coronavirus 2 in breast milk of lactating women vaccinated with BNT162b2 Pfizer-BioNTech coronavirus disease 2019 vaccine (LacCOVID)
Quantification and progress over time of specific antibodies against severe acute respiratory syndrome coronavirus 2 in breast milk of lactating women vaccinated with BNT162b2 Pfizer-BioNTech coronavirus disease 2019 vaccine (LacCOVID)
Citació
- Esteve-Palau E, Gonzalez-Cuevas A, Guerrero ME, Garcia-Terol C, Alvarez MC, Garcia G, et al. Quantification and progress over time of specific antibodies against severe acute respiratory syndrome coronavirus 2 in breast milk of lactating women vaccinated with BNT162b2 Pfizer-BioNTech coronavirus disease 2019 vaccine (LacCOVID). Open Forum Infect Dis. 2022 May 11; 9(6): ofac239. DOI: 10.1093/ofid/ofac239
Enllaç permanent
Descripció
Resum
Background: several observational studies demonstrated the passage of postvaccine antibodies through breast milk in women vaccinated against coronavirus disease 2019 (COVID-19), mostly with messenger RNA (mRNA)-based vaccines, but lacked long-term data. Methods: a 6-month prospective cohort study was performed to determine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-induced antibody levels in the breast milk of 33 lactating healthcare workers at different timepoints after mRNA BNT162b2 Pfizer-BioNTech COVID-19 vaccination. Moreover, we examined the correlation of SARS-CoV-2 antibody levels between serum and breast milk, adverse events related to vaccination, and rate of SARS-CoV-2 infections. Results: mothers' median age was 38 (interquartile range [IQR], 36-39) years and 15 (IQR, 10-22) months for infants. Median (IQR) SARS-CoV-2 immunoglobulin G (IgG) spike protein subunit S1 (S1) vaccine-induced levels at different timepoints for serum-milk pairs were 519 (234-937) to 1 (0-2.9) arbitrary units (AU)/mL at 2 weeks after first dose and 18 644 (9923-29 264) to 78 (33.7-128), 12 478 (6870-20 801) to 50.4 (24.3-104), 4094 (2413-8480) to 19.9 (10.8-51.9), 1350 (831-2298) to 8.9 (7.8-31.5) AU/mL at 2, 4, 12 and 24 weeks after second dose, respectively. We observed a positive correlation of antibody levels between serum and breast milk, no serious adverse events related to vaccination, and 2 (6%) COVID-19 vaccine breakthrough infections. Conclusions: women vaccinated with Pfizer-BioNTech transmit antibodies into breast milk with a positive correlation with serum levels. Both decreased over time in a 6-month follow-up.Col·leccions
Mostra el registre complet