Vitellogenins - yolk gene function and regulation in Caenorhabditis elegans
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- dc.contributor.author Perez, Marcos Francisco, 1987-
- dc.contributor.author Lehner, Ben, 1978-
- dc.date.accessioned 2019-10-24T09:45:22Z
- dc.date.available 2019-10-24T09:45:22Z
- dc.date.issued 2019
- dc.description.abstract Vitellogenins are a family of yolk proteins that are by far the most abundant among oviparous animals. In the model nematode Caenorhabditis elegans, the 6 vitellogenins are among the most highly expressed genes in the adult hermaphrodite intestine, which produces copious yolk to provision eggs. In this article we review what is known about the vitellogenin genes and proteins in C. elegans, in comparison with vitellogenins in other taxa. We argue that the primary purpose of abundant vitellogenesis in C. elegans is to support post-embryonic development and fertility, rather than embryogenesis, especially in harsh environments. Increasing vitellogenin provisioning underlies several post-embryonic phenotypic alterations associated with advancing maternal age, demonstrating that vitellogenins can act as an intergenerational signal mediating the influence of parental physiology on progeny. We also review what is known about vitellogenin regulation - how tissue-, sex- and stage-specificity of expression is achieved, how vitellogenins are regulated by major signaling pathways, how vitellogenin expression is affected by extra-intestinal tissues and how environmental experience affects vitellogenesis. Lastly, we speculate whether C. elegans vitellogenins may play other roles in worm physiology.
- dc.description.sponsorship The work in BL’s lab was supported by a European Research Council (ERC) Consolidator Grant (616434), the Spanish Ministry of Economy and Competitiveness (BFU2017-89488-P and SEV-2012-0208), the AXA Research Fund, the Bettencourt Schueller Foundation, Agencia de Gestio d’Ajuts Universitaris i de Recerca (AGAUR, SGR-831), the EMBL Partnership, and the CERCA Program/Generalitat de Catalunya. MP was funded in part by a Severo Ochoa Ph.D. fellowship.
- dc.format.mimetype application/pdf
- dc.identifier.citation Perez MF, Lehner B. Vitellogenins - yolk gene function and regulation in Caenorhabditis elegans. Front Physiol. 2019;10:1067. DOI: 10.3389/fphys.2019.01067
- dc.identifier.doi http://dx.doi.org/10.3389/fphys.2019.01067
- dc.identifier.issn 1664-042X
- dc.identifier.uri http://hdl.handle.net/10230/42499
- dc.language.iso eng
- dc.publisher Frontiers
- dc.relation.ispartof Frontiers in Physiology. 2019;10:1067
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/616434
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-89488-P
- dc.rights © 2019 Perez and Lehner. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Elegans
- dc.subject.keyword Embryogenesis
- dc.subject.keyword Gene
- dc.subject.keyword Nematode
- dc.subject.keyword Regulation
- dc.subject.keyword Roundworm
- dc.subject.keyword Vitellogenin
- dc.subject.keyword Yolk
- dc.title Vitellogenins - yolk gene function and regulation in Caenorhabditis elegans
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion