Genotyping the high altitude mestizo ecuadorian population affected with prostate cancer
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- dc.contributor.author López Cortés, Andrésca
- dc.contributor.author Cabrera-Andrade, Alejandroca
- dc.contributor.author Salazar Ruales, Carolinaca
- dc.contributor.author Zambrano, Ana Karinaca
- dc.contributor.author Guerrero Jijon, Santiago Xavierca
- dc.contributor.author Guevara-Ramírez, Patriciaca
- dc.contributor.author Leone, Paola E.ca
- dc.contributor.author Paz-y-Miño, Césarca
- dc.date.accessioned 2018-05-15T07:15:30Z
- dc.date.available 2018-05-15T07:15:30Z
- dc.date.issued 2017
- dc.description.abstract Prostate cancer (PC) is the second most commonly diagnosed type of cancer in males with 1,114,072 new cases in 2015. The MTHFR enzyme acts in the folate metabolism, which is essential in methylation and synthesis of nucleic acids. MTHFR C677T alters homocysteine levels and folate assimilation associated with DNA damage. Androgens play essential roles in prostate growth. The SRD5A2 enzyme metabolizes testosterone and the V89L polymorphism reduces in vivo SRD5A2 activity. The androgen receptor gene codes for a three-domain protein that contains two polymorphic trinucleotide repeats (CAG, GGC). Therefore, it is essential to know how PC risk is associated with clinical features and polymorphisms in high altitude Ecuadorian mestizo populations. We analyzed 480 healthy and 326 affected men from our three retrospective case-control studies. We found significant association between MTHFR C/T (odds ratio [OR] = 2.2; P = 0.009), MTHFR C/T+T/T (OR = 2.22; P = 0.009), and PC. The SRD5A2 A49T substitution was associated with higher pTNM stage (OR = 2.88; P = 0.039) and elevated Gleason grade (OR = 3.15; P = 0.004). Additionally, patients with ≤21 CAG repeats have an increased risk of developing PC (OR = 2.99; P < 0.001). In conclusion, genotype polymorphism studies are important to characterize genetic variations in high altitude mestizo populations.
- dc.format.mimetype application/pdf
- dc.identifier.citation López-Cortés A, Cabrera-Andrade A, Salazar-Ruales C, Zambrano AK, Guerrero S, Guevara P et al. Genotyping the High Altitude Mestizo Ecuadorian Population Affected with Prostate Cancer. Biomed Res Int. 2017;2017:3507671. DOI: 10.1155/2017/3507671
- dc.identifier.doi http://dx.doi.org/10.1155/2017/3507671
- dc.identifier.issn 2314-6133
- dc.identifier.uri http://hdl.handle.net/10230/34634
- dc.language.iso eng
- dc.publisher Hindawica
- dc.relation.ispartof Biomed Res Int. 2017;2017:3507671
- dc.rights Copyright © 2017 Andrés López-Cortés et al. This is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Genotype polymorphism studies
- dc.subject.keyword Prostate cancer
- dc.subject.keyword High altitude mestizo populations
- dc.title Genotyping the high altitude mestizo ecuadorian population affected with prostate cancerca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion