Sweet taste preference: Relationships with other tastes, liking for sugary foods and exploratory genome-wide association analysis in subjects with metabolic syndrome

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• dc.contributor.author Fernández-Carrión, Rebeca
• dc.contributor.author Sorlí, José Vicente
• dc.contributor.author Coltell, Oscar
• dc.contributor.author Pascual, Eva C.
• dc.contributor.author Ortega-Azorín, Carolina
• dc.contributor.author Barragán, Rocio
• dc.contributor.author Giménez-Alba, Ignacio M.
• dc.contributor.author Alvarez-Sala, Andrea
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Ordovás, José M.
• dc.contributor.author Corella, Dolores
• dc.date.accessioned 2022-07-28T15:12:44Z
• dc.date.available 2022-07-28T15:12:44Z
• dc.date.issued 2021
• dc.description.abstract Taste perception and its association with nutrition and related diseases (type 2 diabetes, obesity, metabolic syndrome, cardiovascular, etc.) are emerging fields of biomedicine. There is currently great interest in investigating the environmental and genetic factors that influence sweet taste and sugary food preferences for personalized nutrition. Our aims were: (1) to carry out an integrated analysis of the influence of sweet taste preference (both in isolation and in the context of other tastes) on the preference for sugary foods and its modulation by type 2 diabetes status; (2) as well as to explore new genetic factors associated with sweet taste preference. We studied 425 elderly white European subjects with metabolic syndrome and analyzed taste preference, taste perception, sugary-foods liking, biochemical and genetic markers. We found that type 2 diabetic subjects (38%) have a small, but statistically higher preference for sweet taste (p = 0.021) than non-diabetic subjects. No statistically significant differences (p > 0.05) in preferences for the other tastes (bitter, salty, sour or umami) were detected. For taste perception, type 2 diabetic subjects have a slightly lower perception of all tastes (p = 0.026 for the combined "total taste score"), bitter taste being statistically lower (p = 0.023). We also carried out a principal component analysis (PCA), to identify latent variables related to preferences for the five tastes. We identified two factors with eigenvalues >1. Factor 2 was the one with the highest correlation with sweet taste preference. Sweet taste preference was strongly associated with a liking for sugary foods. In the exploratory SNP-based genome-wide association study (GWAS), we identified some SNPs associated with sweet taste preference, both at the suggestive and at the genome-wide level, especially a lead SNP in the PTPRN2 (Protein Tyrosine Phosphatase Receptor Type N2) gene, whose minor allele was associated with a lower sweet taste preference. The PTPRN2 gene was also a top-ranked gene obtained in the gene-based exploratory GWAS analysis. In conclusion, sweet taste preference was strongly associated with sugary food liking in this population. Our exploratory GWAS identified an interesting candidate gene related with sweet taste preference, but more studies in other populations are required for personalized nutrition.
• dc.description.sponsorship This study was partially funded, by the Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana (grants PROMETEO 17/2017, PROMETEO/2021/021, APOSTD/2019/136 and APOSTD/2020/164); the Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (FEDER) (grants CIBER 06/03, PI06/1326, PI13/00728, PI16/00366, PI19/00781 and SAF2016–80532-R); grant PID2019-108858RB-I00 funded by AEI 10.13039/501100011033 and by “ERDF A way of making Europe”; the University Jaume I (grants UJI-B2018-69 and COGRUP/2016/06); the Ministerio de Universidad y Ciencia (FPU 18/01703); the Rei Jaume I Award for Medical Research 2018; and the US Department of Agriculture, Agriculture Research Service (grant 8050-51000-098-00D).
• dc.format.mimetype application/pdf
• dc.identifier.citation Fernández-Carrión R, Sorlí JV, Coltell O, Pascual EC, Ortega-Azorín C, Barragán R, Giménez-Alba IM, Alvarez-Sala A, Fitó M, Ordovas JM, Corella D. Sweet taste preference: Relationships with other tastes, liking for sugary foods and exploratory genome-wide association analysis in subjects with metabolic syndrome. Biomedicines. 2021 Dec 31;10(1):79. DOI: 10.3390/biomedicines10010079
• dc.identifier.doi http://dx.doi.org/10.3390/biomedicines10010079
• dc.identifier.issn 2227-9059
• dc.identifier.uri http://hdl.handle.net/10230/53878
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Biomedicines. 2021 Dec 31;10(1):79
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016–80532-R
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-108858RB-I00
• dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword GWAS
• dc.subject.keyword Biomedicine
• dc.subject.keyword Genetic markers
• dc.subject.keyword Personalized nutrition
• dc.subject.keyword Sugary foods
• dc.subject.keyword Sweet taste preference
• dc.subject.keyword Taste perception
• dc.subject.keyword Type 2 diabetes
• dc.title Sweet taste preference: Relationships with other tastes, liking for sugary foods and exploratory genome-wide association analysis in subjects with metabolic syndrome
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion