Dementia prevention in memory clinics: recommendations from the European task force for brain health services
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- dc.contributor.author Frisoni, Giovanni B.
- dc.contributor.author Minguillón, Carolina
- dc.contributor.author Dubois, Bruno
- dc.date.accessioned 2024-05-23T13:49:22Z
- dc.date.available 2024-05-23T13:49:22Z
- dc.date.issued 2023
- dc.description.abstract Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished, possibly as an unintended result of better vascular prevention and healthier lifestyles. Population aging in the coming decades requires deliberate efforts to further decrease its prevalence and societal burden. Increasing evidence supports the efficacy of preventive interventions on persons with intact cognition and high dementia risk. We report recommendations for the deployment of second-generation memory clinics (Brain Health Services) whose mission is evidence-based and ethical dementia prevention in at-risk individuals. The cornerstone interventions consist of (i) assessment of genetic and potentially modifiable risk factors including brain pathology, and risk stratification, (ii) risk communication with ad-hoc protocols, (iii) risk reduction with multi-domain interventions, and (iv) cognitive enhancement with cognitive and physical training. A roadmap is proposed for concept validation and ensuing clinical deployment.
- dc.description.sponsorship GC has received research support from the European Commission Horizon 2020 research and innovation programme (grant agreement number 667696), Fondation d'entreprise MMA des Entrepreneurs du Futur, Fondation Alzheimer, Programme Hospitalier de Recherche Clinique, Agence Nationale de la Recherche, Région Normandie, Association France Alzheimer et maladies apparentées, Fondation Vaincre Alzheimer, Fondation Recherche Alzheimer and Fondation pour la Recherche Médicale (all to Inserm), and personal fees from Inserm, Fondation Alzheimer and Fondation d'entreprise MMA des Entrepreneurs du Futur.
- dc.format.mimetype application/pdf
- dc.identifier.citation Frisoni GB, Altomare D, Ribaldi F, Villain N, Brayne C, Mukadam N, et al. Dementia prevention in memory clinics: recommendations from the European task force for brain health services. Lancet Reg Health Eur. 2023 Jan 31;26:100576. DOI: 10.1016/j.lanepe.2022.100576
- dc.identifier.doi http://dx.doi.org/10.1016/j.lanepe.2022.100576
- dc.identifier.issn 2666-7762
- dc.identifier.uri http://hdl.handle.net/10230/60236
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Lancet Reg Health Eur. 2023 Jan 31;26:100576
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/667696
- dc.rights © 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Cognitive enhancement
- dc.subject.keyword Dementia
- dc.subject.keyword Memory clinic
- dc.subject.keyword Prevention
- dc.subject.keyword Risk assessment
- dc.subject.keyword Risk communication
- dc.subject.keyword Risk reduction
- dc.title Dementia prevention in memory clinics: recommendations from the European task force for brain health services
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion