Risk of breast cancer after false-positive results in mammographic screening.
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- dc.contributor.author Román, Martaca
- dc.contributor.author Castells, Xavierca
- dc.contributor.author Hofvind, Solveigca
- dc.contributor.author von Euler-Chelpin, M.ca
- dc.date.accessioned 2016-09-07T08:22:30Z
- dc.date.available 2016-09-07T08:22:30Z
- dc.date.issued 2016
- dc.description.abstract Women with false-positive results are commonly referred back to routine screening. Questions remain regarding their long-term outcome of breast cancer. We assessed the risk of screen-detected breast cancer in women with false-positive results. We conducted a joint analysis using individual level data from the population-based screening programs in Copenhagen and Funen in Denmark, Norway, and Spain. Overall, 150,383 screened women from Denmark (1991-2008), 612,138 from Norway (1996-2010), and 1,172,572 from Spain (1990-2006) were included. Poisson regression was used to estimate the relative risk (RR) of screen-detected cancer for women with false-positive versus negative results. We analyzed information from 1,935,093 women 50-69 years who underwent 6,094,515 screening exams. During an average 5.8 years of follow-up, 230,609 (11.9%) women received a false-positive result and 27,849 (1.4%) were diagnosed with screen-detected cancer. The adjusted RR of screen-detected cancer after a false-positive result was 2.01 (95% CI: 1.93-2.09). Women who tested false-positive at first screen had a RR of 1.86 (95% CI: 1.77-1.96), whereas those who tested false-positive at third screening had a RR of 2.42 (95% CI: 2.21-2.64). The RR of breast cancer at the screening test after the false-positive result was 3.95 (95% CI: 3.71-4.21), whereas it decreased to 1.25 (95% CI: 1.17-1.34) three or more screens after the false-positive result. Women with false-positive results had a twofold risk of screen-detected breast cancer compared to women with negative tests. The risk remained significantly higher three or more screens after the false-positive result. The increased risk should be considered when discussing stratified screening strategies.ca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Román M, Castells X, Hofvind S, von Euler-Chelpin M. Risk of breast cancer after false-positive results in mammographic screening. Cancer Med. 2016 Jun;5(6):1298-306. doi: 10.1002/cam4.646ca
- dc.identifier.doi http://dx.doi.org/10.1002/cam4.646
- dc.identifier.issn 2045-7634
- dc.identifier.uri http://hdl.handle.net/10230/27279
- dc.language.iso engca
- dc.publisher Wileyca
- dc.relation.ispartof Cancer Medicine. 2016 Jun;5(6):1298-306
- dc.rights © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of thehttps://creativecommons.org/licenses/by/4.0/ , which permits use, distribution and reproduction in any medium, provided the original work is properly cited.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri https://creativecommons.org/licenses/by/4.0/ca
- dc.subject.other Mama -- Radiografiaca
- dc.subject.other Mama -- Càncerca
- dc.title Risk of breast cancer after false-positive results in mammographic screening.ca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca