Genomic analysis of 18th-century Kazakh individuals and their oral microbiome

White, Anna E.; Dios Martínez, Toni de, 1994-; Carrión, Pablo; Bonora, Gian Luca; Llovera Nadal, Laia; Cilli, Elisabetta; Lizano González, Esther, 1974-; Khabdulina, Maral K.; Tleugabulov, Daniyar T.; Olalde Marquínez, Íñigo, 1987-; Marquès i Bonet, Tomàs, 1975-; Balloux, François; Pettener, Davide; van Dorp, Lucy; Luiselli, Donata; Lalueza Fox, Carles, 1965-

Genomic analysis of 18th-century Kazakh individuals and their oral microbiome

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dc.contributor.author White, Anna E.
dc.contributor.author Dios Martínez, Toni de, 1994-
dc.contributor.author Carrión, Pablo
dc.contributor.author Bonora, Gian Luca
dc.contributor.author Llovera Nadal, Laia
dc.contributor.author Cilli, Elisabetta
dc.contributor.author Lizano González, Esther, 1974-
dc.contributor.author Khabdulina, Maral K.
dc.contributor.author Tleugabulov, Daniyar T.
dc.contributor.author Olalde Marquínez, Íñigo, 1987-
dc.contributor.author Marquès i Bonet, Tomàs, 1975-
dc.contributor.author Balloux, François
dc.contributor.author Pettener, Davide
dc.contributor.author van Dorp, Lucy
dc.contributor.author Luiselli, Donata
dc.contributor.author Lalueza Fox, Carles, 1965-
dc.date.accessioned 2022-01-13T06:43:23Z
dc.date.available 2022-01-13T06:43:23Z
dc.date.issued 2021
dc.description.abstract The Asian Central Steppe, consisting of current-day Kazakhstan and Russia, has acted as a highway for major migrations throughout history. Therefore, describing the genetic composition of past populations in Central Asia holds value to understanding human mobility in this pivotal region. In this study, we analyse paleogenomic data generated from five humans from Kuygenzhar, Kazakhstan. These individuals date to the early to mid-18th century, shortly after the Kazakh Khanate was founded, a union of nomadic tribes of Mongol Golden Horde and Turkic origins. Genomic analysis identifies that these individuals are admixed with varying proportions of East Asian ancestry, indicating a recent admixture event from East Asia. The high amounts of DNA from the anaerobic Gram-negative bacteria Tannerella forsythia, a periodontal pathogen, recovered from their teeth suggest they may have suffered from periodontitis disease. Genomic analysis of this bacterium identified recently evolved virulence and glycosylation genes including the presence of antibiotic resistance genes predating the antibiotic era. This study provides an integrated analysis of individuals with a diet mostly based on meat (mainly horse and lamb), milk, and dairy products and their oral microbiome.
dc.description.sponsorship C.L.-F. is supported by a PGC2018-0955931-B-100 grant (MCIU/AEI/FEDER, UE) of Spain; T.M.-B. is supported by funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 864203), BFU2017-86471-P (MINECO/FEDER, UE), “Unidad de Excelencia María de Maeztu”, funded by the AEI (CEX2018-000792-M), Howard Hughes International Early Career, Secretaria d’Universitats i Recerca and CERCA Programme del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2017 SGR 880). L.v.D. is supportd by a UCL Excellence Fellowship. The Ministry of the Education and Science of the Republic of Kazakhstan permitted and granted the research and the study (Grant number AP09261134). Additional financial contribution was provided by the ISMEO of Rome.
dc.format.mimetype application/pdf
dc.identifier.citation White AE, de-Dios T, Carrión P, Bonora GL, Llovera L, Cilli E, Lizano E, Khabdulina MK, Tleugabulov DT, Olalde I, Marquès-Bonet T, Balloux F, Pettener D, van Dorp L, Luiselli D, Lalueza-Fox C. Genomic analysis of 18th-century Kazakh individuals and their oral microbiome. Biology (Basel). 2021;10(12):1324. DOI: 10.3390/biology10121324
dc.identifier.doi http://dx.doi.org/10.3390/biology10121324
dc.identifier.issn 2079-7737
dc.identifier.uri http://hdl.handle.net/10230/52202
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Biology (Basel). 2021;10(12):1324
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/864203
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-0955931-B-100
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-86471-P
dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Central Asian steppe
dc.subject.keyword Ancient pathogens
dc.subject.keyword Bacteria
dc.subject.keyword Paleogenomics
dc.subject.keyword Red complex
dc.title Genomic analysis of 18th-century Kazakh individuals and their oral microbiome
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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